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电场刺激电极的发展有助于研究生物细胞机制并提高癌症治疗效果。

The Electrode Modality Development in Pulsed Electric Field Treatment Facilitates Biocellular Mechanism Study and Improves Cancer Ablation Efficacy.

机构信息

The Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health and The Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.

The Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.

出版信息

J Healthc Eng. 2017;2017:3624613. doi: 10.1155/2017/3624613. Epub 2017 May 7.

DOI:10.1155/2017/3624613
PMID:29065589
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5438864/
Abstract

Pulsed electric field treatment is now widely used in diverse biological and medical applications: gene delivery, electrochemotherapy, and cancer therapy. This minimally invasive technique has several advantages over traditional ablation techniques, such as nonthermal elimination and blood vessel spare effect. Different electrodes are subsequently developed for a specific treatment purpose. Here, we provide a systematic review of electrode modality development in pulsed electric field treatment. For electrodes invented for experiment in vitro, sheet electrode and electrode cuvette, electrodes with high-speed fluorescence imaging system, electrodes with patch-clamp, and electrodes with confocal laser scanning microscopy are introduced. For electrodes invented for experiment in vivo, monopolar electrodes, five-needle array electrodes, single-needle bipolar electrode, parallel plate electrodes, and suction electrode are introduced. The pulsed electric field provides a promising treatment for cancer.

摘要

电场脉冲治疗目前广泛应用于多种生物医学领域

基因传递、电化学疗法和癌症治疗。与传统的消融技术相比，这种微创技术具有非热消除和血管保留效应等多种优势。随后，为了特定的治疗目的，开发了不同的电极。本文系统地综述了电场脉冲治疗中电极模式的发展。对于体外实验中发明的电极，本文介绍了平板电极和电极比色皿、带有高速荧光成像系统的电极、带有膜片钳的电极和带有共聚焦激光扫描显微镜的电极。对于体内实验中发明的电极，本文介绍了单极电极、五针阵列电极、单针双极电极、平行板电极和抽吸电极。电场脉冲为癌症治疗提供了一种很有前途的方法。

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