Rolston John D, Gross Robert E, Potter Steve M
Department of Neurological Surgery, Emory University School of Medicine, Atlanta, GA 30322, USA.
Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:6489-92. doi: 10.1109/IEMBS.2009.5333589.
Closed-loop systems, where neural signals are used to control electrical stimulation, show promise as powerful experimental platforms and nuanced clinical therapies. To increase the availability, affordability, and usability of these devices, we have created a flexible open source system capable of simultaneous stimulation and recording from multiple electrodes. The system is versatile, functioning with both freely moving animals and in vitro preparations. Current- and voltage-controlled stimulation waveforms with 1 micros resolution can be delivered to any electrode of an array. Stimulation sequences can be preprogrammed or triggered by ongoing neural activity, such as action potentials (APs) or local field potentials (LFPs). Recovery from artifact is rapid, allowing the detection of APs within 1 ms of stimulus offset. Since the stimulation subsystem provides simultaneous current/voltage monitoring, electrode impedance spectra can be calculated in real time. A sample closed-loop experiment is presented wherein interictal spikes from epileptic animals are used to trigger microstimulation.
闭环系统利用神经信号来控制电刺激，有望成为强大的实验平台和精细的临床治疗手段。为了提高这些设备的可用性、可承受性和易用性，我们创建了一个灵活的开源系统，能够同时从多个电极进行刺激和记录。该系统用途广泛，适用于自由活动的动物和体外制备。具有1微秒分辨率的电流控制和电压控制刺激波形可以输送到阵列的任何电极。刺激序列可以预先编程或由正在进行的神经活动触发，如动作电位（APs）或局部场电位（LFPs）。伪迹恢复迅速，能够在刺激结束后1毫秒内检测到动作电位。由于刺激子系统提供同时的电流/电压监测，电极阻抗谱可以实时计算。本文展示了一个样本闭环实验，其中来自癫痫动物的发作间期尖峰被用于触发微刺激。
