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用于荧光寿命对比的近红外染料工程

Engineering NIR dyes for fluorescent lifetime contrast.

作者信息

Berezin Mikhail Y, Lee Hyeran, Akers Walter, Guo Kevin, Goiffon Reece J, Almutairi Adah, Fréchet Jean M J, Achilefu Samuel

机构信息

Washington University School of Medicine, Department of Radiology, St. Louis, MO 63110, USA.

出版信息

Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:114-7. doi: 10.1109/IEMBS.2009.5334834.

DOI:10.1109/IEMBS.2009.5334834
PMID:19964923
Abstract

The excited state of an organic molecule is a crossroads which can lead to many directions, such as non-radiative emission as heat, fluorescence, intersystem crossing and phosphorescence. Due to the unpredictable nature of the excited molecular structure, manipulation of this represents significant challenges for physicists and chemists. However, the successful management of the excited state provides a number of benefits with innumerable applications to fields like photonics and medicine. One such property of the excited state with powerful ramifications in medical diagnostics is fluorescence lifetime.

摘要

有机分子的激发态是一个岔路口,它可以通向许多方向,比如以热的形式进行非辐射发射、荧光、系间窜越和磷光。由于激发分子结构的不可预测性,对其进行操控对物理学家和化学家来说是巨大的挑战。然而,对激发态的成功操控带来了许多益处,并在光子学和医学等领域有着无数应用。激发态的一个在医学诊断中有重大影响的特性就是荧光寿命。

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