Bhujwalla Zaver M
JHU ICMIC Program of the Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:47-9. doi: 10.1109/IEMBS.2009.5335068.
Because of the remarkable ability of cancer cells to adapt and survive, finding effective treatments against cancer depends upon identifying and attacking targets and pathways critically important for the cancer cell. The tumor physiological microenvironment, interactions between cancer cells and stromal cells such as endothelial cells, fibroblasts and macrophages, the extracellular matrix, and a multitude of secreted factors and cytokines influence progression, aggressiveness and response of the disease to treatment. Multi-modality and multi-parametric molecular and functional imaging provide unprecedented opportunities for understanding cancer. Some of our recent advances in molecular and functional imaging of cancer are discussed.
由于癌细胞具有显著的适应和生存能力，因此找到有效的癌症治疗方法取决于识别并攻击对癌细胞至关重要的靶点和信号通路。肿瘤的生理微环境、癌细胞与内皮细胞、成纤维细胞和巨噬细胞等基质细胞之间的相互作用、细胞外基质以及大量分泌因子和细胞因子会影响疾病的进展、侵袭性和对治疗的反应。多模态和多参数分子与功能成像为理解癌症提供了前所未有的机会。本文将讨论我们在癌症分子与功能成像方面的一些最新进展。
