Ercan Sümeyye, Cakmak Alpay, Kösecik Mustafa, Erel Ozcan
Department of Pediatrics, Harran University School of Medicine, Sanliurfa, Turkey.
Anadolu Kardiyol Derg. 2009 Dec;9(6):486-90.
The type of congenital heart disease, early diagnosis, and treatment modality all play an important role in the morbidity and mortality of these diseases. This study examined the relationship between congenital heart disease and oxidative stress in children with cyanotic and acyanotic congenital heart disease.
In this case-controlled cross-sectional study, the study groups consisted of 29 patients with cyanotic heart disease, 30 patients with acyanotic heart disease, and a control group of 32 healthy individuals. For all groups, the total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) were calculated. Of the cyanotic group, 12 were diagnosed with tetralogy of Fallot, 7 with transposition of the great arteries, 4 with tricuspid atresia, 4 with double outlet right ventricle and 2 with truncus arteriosus. In the acyanotic group 19 patients had ventricular septal defect (VSD), 5 atrial septal defect (ASD) and 6 patent ductus arteriosus (PDA). Statistical analyses were performed using Chi-square, Mann-Whitney U and Kruskal-Wallis tests.
The plasma TAS, TOS, and OSI were significantly higher in the cyanotic group than in the acyanotic group (p<0.0001, p<0.01, and p<0.01, respectively) and controls (p<0.0001, p<0.0001, and p<0.0001, respectively). A comparison between the acyanotic and control groups showed no statistical differences.
The level of oxidative stress in patients with cyanotic congenital heart disease was significantly higher than in the acyanotic and control groups, which were similar.
先天性心脏病的类型、早期诊断及治疗方式在这些疾病的发病率和死亡率中均起着重要作用。本研究探讨了患有青紫型和非青紫型先天性心脏病儿童的先天性心脏病与氧化应激之间的关系。
在这项病例对照横断面研究中，研究组包括29例青紫型心脏病患者、30例非青紫型心脏病患者以及32名健康个体组成的对照组。对所有组计算总氧化剂状态（TOS）、总抗氧化剂状态（TAS）和氧化应激指数（OSI）。在青紫型组中，12例被诊断为法洛四联症，7例为大动脉转位，4例为三尖瓣闭锁，4例为右心室双出口，2例为动脉干永存。在非青紫型组中，19例患者患有室间隔缺损（VSD），5例患有房间隔缺损（ASD），6例患有动脉导管未闭（PDA）。使用卡方检验、曼-惠特尼U检验和克鲁斯卡尔-沃利斯检验进行统计分析。
青紫型组的血浆TAS、TOS和OSI显著高于非青紫型组（分别为p<0.0001、p<0.01和p<0.01）以及对照组（分别为p<0.0001、p<0.0001和p<0.0001）。非青紫型组与对照组之间的比较未显示出统计学差异。
青紫型先天性心脏病患者的氧化应激水平显著高于非青紫型组和对照组，而后两组相似。
