一项基于 15 年人群的法国老年队列研究帕金森病和路易体痴呆发病率的研究。

A 15-year population-based cohort study of the incidence of Parkinson's disease and dementia with Lewy bodies in an elderly French cohort.

机构信息

Parkinson's Disease and Related Disorders Unit, Department of Clinical Neurosciences, University Hospital, Bordeaux, France.

出版信息

J Neurol Neurosurg Psychiatry. 2010 Jul;81(7):742-6. doi: 10.1136/jnnp.2009.189142. Epub 2009 Dec 3.

DOI:10.1136/jnnp.2009.189142

PMID:19965839

Abstract

OBJECTIVE

To provide global and age-related incidence over 65 years of Parkinsonian syndromes (PS), Parkinson's disease (PD) and suspected dementia with Lewy bodies (DLB).

METHODS

A 15-year prospective population-based elderly cohort study in South-Western France (PAQUID).

RESULTS

Incidences found were: 557.7/100,000 person-years for PS, 263 per 100 000 person-years for PD and 112 per 100,000 person-years for suspected DLB. The incidence of all PS, PD and suspected DLB was greater in men. The age-specific incidence of PD decreased over 85, while that of DLB continuously increased, even in the oldest individuals.

CONCLUSIONS

The authors provide new data on PD and suspected DLB incidence in a large population-based French cohort of subjects aged over 65 and followed up for 15 years. PD incidence decreased in the oldest old contrary to that of suspected DLB cases and Alzheimer's disease.

摘要

目的

提供全球范围内 65 岁以上人群帕金森综合征（PS）、帕金森病（PD）和路易体痴呆症（DLB）疑似病例的发病率及年龄相关性数据。

方法

对法国西南部一项为期 15 年的前瞻性老年人群队列研究（PAQUID）进行分析。

结果

得出的发病率数据为：PS 为 557.7/100000 人年，PD 为 263/100000 人年，疑似 DLB 为 112/100000 人年。所有 PS、PD 和疑似 DLB 的发病率在男性中更高。PD 的年龄特异性发病率在 85 岁以上人群中下降，而 DLB 的发病率持续上升，即使在最年长的个体中也是如此。