Oculoplastics Service, Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin 53792-3284, USA.
Ophthalmic Plast Reconstr Surg. 2009 Sep-Oct;25(5):354-8. doi: 10.1097/IOP.0b013e3181b30358.
To determine a suitable animal model for further characterization of the nasolacrimal drainage system.
A comprehensive Pubmed literature search was performed to locate articles pertaining to the histology or anatomy of the nasolacrimal drainage system in research animals. The histology of 2 nasolacrimal drainage systems of a cynomolgus monkey was also evaluated using hematoxylin-eosin stain.
Sixteen articles were identified that describe the anatomy and/or histology of the nasolacrimal drainage system in rabbits, rats, pigs, sheep, goats, horses, deer, llamas, camels, apes, dogs, and cats, with significant homology between these models. Notable exceptions were found in rat histology and rabbit anatomy. In the few experiments using animal models to investigate the nasolacrimal drainage system, the rabbit model was the most commonly used system. Light microscopy of the cynomolgus monkey nasolacrimal drainage system revealed markedly similar anatomy and histology to that of humans.
Literature review demonstrates a great deal of similarity in the anatomy and histology of the nasolacrimal drainage systems of 12 mammalian species. Although a common ophthalmic research animal, the rat model has significant histologic differences that prevent its use for comparison with the human lacrimal excretory system. Current literature suggests that despite anatomical variation, the rabbit animal model could potentially be used for further characterization of the nasolacrimal drainage system because it pertains to clinical applications in human patients. Preliminary light microscopy suggests that the cynomolgus monkey may be a superior model for nasolacrimal drainage research, but further studies are required.
确定适合进一步研究鼻泪管系统的动物模型。
进行全面的 Pubmed 文献检索，以定位有关研究动物鼻泪管系统组织学或解剖学的文章。还用苏木精-伊红染色评估了 1 只食蟹猴的 2 个鼻泪管系统的组织学。
确定了 16 篇描述兔、大鼠、猪、绵羊、山羊、马、鹿、羊驼、骆驼、猿、犬和猫的鼻泪管系统解剖结构和/或组织学的文章，这些模型之间具有显著的同源性。在大鼠组织学和兔解剖学方面发现了明显的例外。在使用动物模型研究鼻泪管系统的少数实验中，兔模型是最常用的模型。食蟹猴鼻泪管系统的光镜检查显示出与人类非常相似的解剖结构和组织学。
文献综述表明，12 种哺乳动物的鼻泪管系统在解剖结构和组织学上有很大的相似性。尽管大鼠是一种常见的眼科研究动物，但它在组织学上有很大的差异，使其无法与人类的泪液排泄系统进行比较。目前的文献表明，尽管存在解剖学差异，但兔动物模型可能可用于进一步研究鼻泪管系统，因为它与人类患者的临床应用有关。初步的光镜检查表明，食蟹猴可能是鼻泪管研究的更好模型，但需要进一步的研究。
