Mendiratta Vibhu, Khan Anamita, Solanki R S
Department of Dermatology and Venereology and Radio Diagnosis, Lady Hardinge Medical College and Associated Hospitals, New Delhi - 110 001, India.
Indian J Dermatol. 2008 Jan;53(1):28-30. doi: 10.4103/0019-5154.39739.
A patient of pemphigus vulgaris presented with avascular necrosis of the femur after long-term high-dose corticosteroid therapy. Corticosteroids used on a long-term basis can cause avascular necrosis of bone and this has been seen in various diseases. This is attributable to both the disease process itself and the therapy i.e. corticosteroid usage. In dermatological practice avascular necrosis of bone has been seen more commonly with SLE and also with psoriasis using long-term steroids. Avascular necrosis in a case of pemphigus on steroid therapy is a rare finding. We report such a case of pemphigus vulgaris developing avascular necrosis of bone following corticosteroid therapy.
一名寻常型天疱疮患者在长期大剂量使用糖皮质激素治疗后出现股骨缺血性坏死。长期使用糖皮质激素可导致骨缺血性坏死，这在多种疾病中均有发现。这可归因于疾病本身的进程以及治疗，即糖皮质激素的使用。在皮肤科临床实践中，骨缺血性坏死在系统性红斑狼疮以及长期使用类固醇的银屑病患者中更为常见。在接受类固醇治疗的天疱疮患者中出现骨缺血性坏死是一种罕见的情况。我们报告了这样一例寻常型天疱疮患者在糖皮质激素治疗后发生骨缺血性坏死的病例。
