Department of General Surgery, Shanghai Chang Zheng Hospital, Second Military Medical University, 415 Feng Yang Road, 200003 Shanghai, People's Republic of China.
J Cancer Res Clin Oncol. 2010 Jul;136(7):969-74. doi: 10.1007/s00432-009-0740-z. Epub 2009 Dec 5.
Nonfunctional parathyroid carcinoma (PTC) is one of the rarest malignant diseases and only nine cases have been reported during the last 23 years. We present a case of nonfunctioning PTC and review the literature in an effort to provide a better understanding of this rare disorder.
One patient with nonfunctioning PTC was presented, detailing the clinical features, histologic findings, diagnosis, and treatment. Together with data from the other nine cases reported last 23 years, the related literature is also reviewed.
The presented case was a 47-year-old man with a 2-month history of an enlarging painless cervical mass followed by a 2-week history of hoarseness. Clinical and laboratory evaluations failed to reveal evidence of hyperparathyroidism. Pathological analysis of the resected tumor disclosed findings consistent with PTC. The nonsecretory state of the tumor was further supported by immunoreactivity for parathyroid hormone in tissue, and normal serum levels of this peptide and calcium preoperatively and postoperatively.
Most nonfunctional PTC is detected late due to a paucity of symptoms, of which a palpable neck mass is the most common. Patients with nonfunctioning PTC appear to have a poorer prognosis than do those with functioning parathyroid cancers.
无功能性甲状旁腺癌（PTC）是一种罕见的恶性疾病，在过去的 23 年中仅报道了 9 例。我们报告了 1 例无功能性 PTC 病例，并对文献进行了回顾，旨在更好地了解这种罕见疾病。
报告了 1 例无功能性 PTC 患者，详细描述了其临床特征、组织学发现、诊断和治疗。同时结合过去 23 年中报道的其他 9 例病例的数据，也对相关文献进行了回顾。
所报告的病例是一名 47 岁男性，有 2 个月的逐渐增大的无痛性颈肿块史，随后有 2 周的声音嘶哑史。临床和实验室检查均未能发现甲状旁腺功能亢进的证据。切除肿瘤的病理分析显示符合 PTC 的发现。肿瘤的非分泌状态进一步得到组织中甲状旁腺激素免疫反应以及术前和术后该肽和钙的正常血清水平的支持。
由于症状较少，大多数无功能性 PTC 发现较晚，其中可触及的颈部肿块最为常见。与功能性甲状旁腺癌患者相比，无功能性 PTC 患者的预后似乎更差。
