Newton T A, Rose S R
Division of Emergency Medicine, University of Florida Health Science Center, Jacksonville 32209.
Ann Emerg Med. 1991 Feb;20(2):204-7. doi: 10.1016/s0196-0644(05)81225-9.
Phenylbutazone is a potent nonsteroidal, anti-inflammatory drug often used by veterinarians to treat racetrack animals. Its use in human beings is limited because of significant adverse effects and the availability of newer, safer drugs. We report the case of a 24-year-old man who ingested 17 g of equine phenylbutazone over a 24-hour period to treat the pain of a toothache. He developed grand mal seizures, coma, hypotension, respiratory and renal failure, and hepatic injury. Serum phenylbutazone concentration obtained approximately eight hours after presentation was 900 micrograms/mL. The patient recovered during six weeks of intensive supportive care and repeated hemodialysis.
保泰松是一种强效非甾体抗炎药，兽医常用它来治疗赛马等动物。由于其显著的不良反应以及有更新、更安全的药物可供使用，它在人类中的使用受到限制。我们报告一例24岁男性病例，该患者在24小时内服用了17克马用保泰松来治疗牙痛。他出现了癫痫大发作、昏迷、低血压、呼吸和肾衰竭以及肝损伤。就诊后约8小时测得的血清保泰松浓度为900微克/毫升。该患者在六周的强化支持治疗和反复血液透析后康复。
