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[可生物降解内固定材料的研究进展]

[Progress of biodegradable internal fixation materials].

作者信息

Su Bao, Jiang Dianming

机构信息

Department of Orthopaedics, First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, PR China.

出版信息

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2009 Nov;23(11):1388-92.

PMID:19968186
Abstract

OBJECTIVE

To sum up the recent progress of common biodegradable internal fixation materials and to forecast the possible directions for further research.

METHODS

The latest original articles about biomechanical properties, degradation characteristics, advantages and disadvantages of biodegradable internal fixation materials were extensively reviewed. Several common biodegradable materials were selected and expounded in different categories.

RESULTS

The disadvantages of stress shielding and the second time removal, could be avoided by using biodegradable internal fixation materials instead of metal materials. Biodegradable internal fixation materials could fix fracture stably and they were ideal orthopedic internal fixation materials. Natural biodegradable polymers had excellent biocompatibility but poor mechanical strength. Synthetic biodegradable materials could be artificially regulated their degradation rate and had better mechanical strength, however, they had shortcomings in biocompatibility. Composite materials could learn from others' strong points to offset their weakness, therefore, they had pronounced advantages over the former two materials.

CONCLUSION

There still exist many problems in present biodegradable internal fixation materials although they are of great potential in its application. Combining various biomaterials and using the specific processing technology to develop a biodegradable material which has better biomechanical properties, chemical properties and physical structure is the direction for future research.

摘要

目的

总结常见可生物降解内固定材料的最新研究进展,并预测其进一步研究的可能方向。

方法

广泛综述了关于可生物降解内固定材料的生物力学性能、降解特性、优缺点的最新原创文章。选取了几种常见的可生物降解材料并按不同类别进行阐述。

结果

使用可生物降解内固定材料替代金属材料可避免应力遮挡和二次取出的缺点。可生物降解内固定材料能够稳定固定骨折,是理想的骨科内固定材料。天然可生物降解聚合物具有优异的生物相容性,但机械强度较差。合成可生物降解材料可人为调节其降解速率,且具有较好的机械强度,然而,它们在生物相容性方面存在不足。复合材料能够取长补短,因此,与前两种材料相比具有明显优势。

结论

目前的可生物降解内固定材料尽管在应用中具有巨大潜力,但仍存在许多问题。结合各种生物材料并采用特定加工技术开发具有更好生物力学性能、化学性能和物理结构的可生物降解材料是未来研究的方向。

相似文献

1
[Progress of biodegradable internal fixation materials].[可生物降解内固定材料的研究进展]
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2009 Nov;23(11):1388-92.
2
[Progress of bone graft substitute].[骨移植替代物的进展]
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2008 Oct;22(10):1264-8.
3
[Orthopaedic applications for biodegradable and absorbable internal fixation of fractures].[可生物降解和可吸收内固定材料在骨折治疗中的骨科应用]
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2002 May;16(3):209-11.
4
Future materials for foot surgery.足部手术的未来材料
Clin Podiatr Med Surg. 1995 Jul;12(3):519-44.
5
Mechanical properties of biodegradable polymers and composites proposed for internal fixation of bone.用于骨内固定的可生物降解聚合物及复合材料的力学性能
J Appl Biomater. 1990 Spring;1(1):57-78. doi: 10.1002/jab.770010109.
6
Bioresorbable composite materials for orthopaedic devices.用于骨科器械的生物可吸收复合材料。
Med Device Technol. 2008 Sep;19(5):69-70, 72.
7
Bioresorbable fracture fixation in orthopedics: a comprehensive review. Part I. Basic science and preclinical studies.骨科生物可吸收骨折内固定:综述。第一部分。基础科学与临床前研究。
Am J Orthop (Belle Mead NJ). 1997 Oct;26(10):665-71.
8
Complications after zygoma fracture fixation: is there a difference between biodegradable materials and how do they compare with titanium osteosynthesis?颧骨骨折固定术后并发症:可生物降解材料之间是否存在差异,以及它们与钛质骨固定术相比如何?
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Apr;101(4):419-25. doi: 10.1016/j.tripleo.2005.07.026. Epub 2006 Jan 19.
9
[Development of biodegradable polymer scaffolds for bone tissue engineering].[用于骨组织工程的可生物降解聚合物支架的研发]
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2000 May;14(3):175-80.
10
Bioresorbable fracture fixation in orthopedics: a comprehensive review. Part II. Clinical studies.骨科生物可吸收骨折内固定:综述。第二部分。临床研究。
Am J Orthop (Belle Mead NJ). 1997 Nov;26(11):754-62.

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