Su Bao, Jiang Dianming
Department of Orthopaedics, First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, PR China.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2009 Nov;23(11):1388-92.
To sum up the recent progress of common biodegradable internal fixation materials and to forecast the possible directions for further research.
The latest original articles about biomechanical properties, degradation characteristics, advantages and disadvantages of biodegradable internal fixation materials were extensively reviewed. Several common biodegradable materials were selected and expounded in different categories.
The disadvantages of stress shielding and the second time removal, could be avoided by using biodegradable internal fixation materials instead of metal materials. Biodegradable internal fixation materials could fix fracture stably and they were ideal orthopedic internal fixation materials. Natural biodegradable polymers had excellent biocompatibility but poor mechanical strength. Synthetic biodegradable materials could be artificially regulated their degradation rate and had better mechanical strength, however, they had shortcomings in biocompatibility. Composite materials could learn from others' strong points to offset their weakness, therefore, they had pronounced advantages over the former two materials.
There still exist many problems in present biodegradable internal fixation materials although they are of great potential in its application. Combining various biomaterials and using the specific processing technology to develop a biodegradable material which has better biomechanical properties, chemical properties and physical structure is the direction for future research.
总结常见可生物降解内固定材料的最新研究进展,并预测其进一步研究的可能方向。
广泛综述了关于可生物降解内固定材料的生物力学性能、降解特性、优缺点的最新原创文章。选取了几种常见的可生物降解材料并按不同类别进行阐述。
使用可生物降解内固定材料替代金属材料可避免应力遮挡和二次取出的缺点。可生物降解内固定材料能够稳定固定骨折,是理想的骨科内固定材料。天然可生物降解聚合物具有优异的生物相容性,但机械强度较差。合成可生物降解材料可人为调节其降解速率,且具有较好的机械强度,然而,它们在生物相容性方面存在不足。复合材料能够取长补短,因此,与前两种材料相比具有明显优势。
目前的可生物降解内固定材料尽管在应用中具有巨大潜力,但仍存在许多问题。结合各种生物材料并采用特定加工技术开发具有更好生物力学性能、化学性能和物理结构的可生物降解材料是未来研究的方向。