Song Ke-guan, Ma De-sheng, Cheng Cheng-Kung, Yan Jing-long
Department of Orthopedic Surgery, First Clinical Hospital of Harbin Medical University, Youzheng Harbin, Heilongjiang 150001, China.
Orthopedics. 2009 Dec;32(12):890. doi: 10.3928/01477447-20091020-07.
The impact of the dog's morselized autologous bone implantation into femoral medullary cavity on binding in the hydroxyapatite-coated femoral stem prosthesis-bone interface was studied. Twenty-four adult mongrel dogs were divided into 2 groups: experimental and control. The experimental group's medullary cavity was filled with morselized autologous bone. Artificial femoral-stem replacements at the right side were then carried out. At 1, 3, and 6 months postoperatively, computed tomography (CT) values reflecting changes in bone density were measured. A histological observation to check prosthesis-bone interface contact ratios and bone growth was conducted. Analysis of radiographs of slices was made using Interactive Data Language (IDL; ITT Visual Information Solutions, Boulder, Colorado) software. Results showed that the experimental group fared better than the control group, and the difference was statistically significant (P<.05). Stereomicroscope-based observation showed that the number of trabecular bones in the experimental group was larger than that of the control group, and bone growth of the experimental group was also better than that of the control group. Inverted microscope observation showed that the binding degree between prosthesis and trabecular bone of the experimental group was higher than that of the control group. Comparatively, the experimental group's trabecular bone had more osteogenic cells. The binding between morselized autologous bone and hydroxyapatite-coated femoral stem prosthesis can improve direct bone-contact ratios, and the experimental group's number of newly formed trabecular bone was significantly larger than that of the control group.
研究了犬自体碎骨植入股骨髓腔对羟基磷灰石涂层股骨柄假体-骨界面结合的影响。将24只成年杂种犬分为2组：实验组和对照组。实验组的髓腔内填充自体碎骨。然后对右侧进行人工股骨柄置换。术后1、3和6个月，测量反映骨密度变化的计算机断层扫描（CT）值。进行组织学观察以检查假体-骨界面接触率和骨生长情况。使用交互式数据语言（IDL；ITT视觉信息解决方案公司，科罗拉多州博尔德）软件对切片的X线照片进行分析。结果显示，实验组的情况优于对照组，差异具有统计学意义（P<0.05）。基于体视显微镜的观察表明，实验组的小梁骨数量多于对照组，实验组的骨生长也优于对照组。倒置显微镜观察显示，实验组假体与小梁骨之间的结合程度高于对照组。相比之下，实验组的小梁骨有成骨细胞较多。自体碎骨与羟基磷灰石涂层股骨柄假体之间的结合可提高直接骨接触率，实验组新形成的小梁骨数量明显多于对照组。
