Centre for Brain Repair, University of Cambridge, Cambridge, UK.
Expert Rev Mol Med. 2009 Dec 8;11:e37. doi: 10.1017/S1462399409001288.
Spinal cord injury is one of the most devastating conditions that affects the central nervous system. It can lead to permanent disability and there are around two million people affected worldwide. After injury, accumulation of myelin debris and formation of an inhibitory glial scar at the site of injury leads to a physical and chemical barrier that blocks axonal growth and regeneration. The mammalian central nervous system thus has a limited intrinsic ability to repair itself after injury. To improve axonal outgrowth and promote functional recovery, it is essential to identify the various intrinsic and extrinsic factors controlling regeneration and navigation of axons within the inhibitory environment of the central nervous system. Recent advances in spinal cord research have opened new avenues for the exploration of potential targets for repairing the cord and improving functional recovery after trauma. Here, we discuss some of the important key molecules that could be harnessed for repairing spinal cord injury.
脊髓损伤是一种最具破坏性的中枢神经系统疾病。它可导致永久性残疾，全世界约有 200 万人受其影响。损伤后，髓磷脂碎片的积累和损伤部位抑制性胶质瘢痕的形成导致了物理和化学屏障，阻止了轴突的生长和再生。因此，哺乳动物中枢神经系统在损伤后自我修复的能力有限。为了改善轴突的生长并促进功能恢复，有必要确定控制轴突在中枢神经系统抑制性环境中再生和导航的各种内在和外在因素。脊髓研究的最新进展为探索修复脊髓和改善创伤后功能恢复的潜在靶点开辟了新途径。在这里，我们讨论了一些可用于修复脊髓损伤的重要关键分子。
