气胸、低血压与脑室内出血的关联。
Association of pneumothorax and hypotension with intraventricular haemorrhage.
作者信息
Mehrabani D, Gowen C W, Kopelman A E
机构信息
Department of Pediatrics, East Carolina School of Medicine, Greenville, North Carolina 27858-4354.
出版信息
Arch Dis Child. 1991 Jan;66(1 Spec No):48-51. doi: 10.1136/adc.66.1_spec_no.48.
To test the hypothesis that acute hypotension resulting from pneumothorax would be associated with severe brain injury (grade 3 or 4 intraventricular haemorrhage), 67 very low birthweight (VLBW) infants of 32 weeks' gestation or less with respiratory distress syndrome and pneumothorax were studied. Thirty six had pneumothorax associated with systemic hypotension and 31 had pneumothorax with normal blood pressure. The groups were similar in gestational age and severity of their respiratory distress syndrome. Thirty two of 36 of infants with pneumothorax associated with hypotension (89%) had grade 3 or 4 intraventricular haemorrhage. This percentage was significantly greater than the percentage for infants with pneumothorax and normal blood pressure (three of 31, 10%). The risk ratio for grade 3 or 4 intraventricular haemorrhage for infants with pneumothorax associated with hypotension was 9.8 compared with neonates with pneumothorax and normal blood pressure. These observations are consistent with the hypothesis that systemic hypotension and cerebral hypoperfusion are important factors leading to intraventricular haemorrhage in VLBW infants.
为验证气胸导致的急性低血压与严重脑损伤（3级或4级脑室内出血）相关这一假说，对67例孕32周及以下、患有呼吸窘迫综合征和气胸的极低出生体重（VLBW）婴儿进行了研究。36例气胸伴全身性低血压，31例气胸但血压正常。两组在胎龄和呼吸窘迫综合征严重程度方面相似。36例气胸伴低血压的婴儿中有32例（89%）发生了3级或4级脑室内出血。这一比例显著高于气胸且血压正常的婴儿（31例中有3例，10%）。气胸伴低血压婴儿发生3级或4级脑室内出血的风险比与气胸且血压正常的新生儿相比为9.8。这些观察结果与全身性低血压和脑灌注不足是导致VLBW婴儿脑室内出血的重要因素这一假说相符。
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