高血压母亲所生婴儿呼吸窘迫综合征的发病率增加。
Increased incidence of respiratory distress syndrome in babies of hypertensive mothers.
作者信息
Tubman T R, Rollins M D, Patterson C, Halliday H L
机构信息
Royal Maternity Hospital, Belfast, Northern Ireland.
出版信息
Arch Dis Child. 1991 Jan;66(1 Spec No):52-4. doi: 10.1136/adc.66.1_spec_no.52.
There is controversy over the effect of hypertension in pregnancy on the incidence of neonatal respiratory distress syndrome. We investigated the association between maternal hypertension and the incidence of respiratory distress syndrome in 268 very low birthweight babies of less than 34 weeks' gestation. A lower incidence of respiratory distress syndrome was associated with growth retardation and membrane rupture greater than 24 hours. Maternal hypertension was associated with an increased incidence of respiratory distress syndrome. We used the multiple logistic regression model to control for confounding variables, as the maternal and neonatal factors associated with respiratory distress syndrome were not evenly distributed between the two groups. After adjustment for birth weight, gestational age, growth retardation, and membrane rupture greater than 24 hours, the risk of developing respiratory distress syndrome was significantly greater in babies of hypertensive mothers. Significance was lost when labour before delivery and mode of delivery were taken into account. The increased incidence of respiratory distress syndrome in babies of hypertensive mothers may be due to the absence of labour before delivery because of the greater likelihood of caesarean section.
妊娠期高血压对新生儿呼吸窘迫综合征发病率的影响存在争议。我们调查了268例孕周小于34周的极低出生体重儿中母亲高血压与呼吸窘迫综合征发病率之间的关联。呼吸窘迫综合征发病率较低与生长发育迟缓以及胎膜破裂超过24小时有关。母亲高血压与呼吸窘迫综合征发病率增加有关。由于与呼吸窘迫综合征相关的母体和新生儿因素在两组之间分布不均，我们使用多元逻辑回归模型来控制混杂变量。在调整出生体重、孕周、生长发育迟缓以及胎膜破裂超过24小时后，高血压母亲的婴儿发生呼吸窘迫综合征的风险显著更高。当考虑分娩前的分娩情况和分娩方式时，这种显著性消失了。高血压母亲的婴儿呼吸窘迫综合征发病率增加可能是由于剖宫产可能性较大导致分娩前未发生分娩。
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