Eindhoven University of Technology, Dept. of Biomedical NMR, Eindhoven, The Netherlands.
J Control Release. 2010 Apr 2;143(1):120-7. doi: 10.1016/j.jconrel.2009.12.002. Epub 2009 Dec 5.
Local drug delivery of doxorubicin holds promise to improve the therapeutic efficacy and to reduce toxicity profiles. Here, we investigated the release of doxorubicin and [Gd(HPDO3A)(H(2)O)] from different temperature-sensitive liposomes for applications in temperature-induced drug delivery under magnetic resonance image guidance. In particular, two temperature-sensitive systems composed of DPPC:MPPC:DPPE-PEG2000 (low temperature-sensitive liposomes, LTSL) and DPPC:HSPC:cholesterol:DPPE-PEG2000 (traditional temperature-sensitive liposomes, TTSL) were investigated. The co-encapsulation of [Gd(HPDO3A)(H(2)O)], a clinically approved MRI contrast agent, did not influence the encapsulation and release of doxorubicin. The LTSL system showed a higher leakage of doxorubicin at 37 degrees C, but a faster release of doxorubicin at 42 degrees C compared to the TTSL system. Furthermore, the rapid release of both doxorubicin and the MRI contrast agent from the liposomes occurred near the melting phase transition temperature, making it possible to image the release of doxorubicin using MRI.
局部药物递送阿霉素有望提高治疗效果，降低毒性。在这里，我们研究了不同温度敏感脂质体中阿霉素和[Gd（HPDO3A）（H2O）]的释放，以用于在磁共振图像引导下进行温度诱导的药物递送。特别是，研究了由 DPPC：MPPC：DPPE-PEG2000（低温敏感脂质体，LTSL）和 DPPC：HSPC：胆固醇：DPPE-PEG2000（传统温度敏感脂质体，TTSL）组成的两种温度敏感系统。共包封[Gd（HPDO3A）（H2O）]，一种临床批准的 MRI 造影剂，不影响阿霉素的包封和释放。与 TTSL 系统相比，LTSL 系统在 37°C 时阿霉素泄漏更高，但在 42°C 时阿霉素释放更快。此外，脂质体中阿霉素和 MRI 造影剂的快速释放发生在接近熔融相变温度附近，因此可以使用 MRI 来成像阿霉素的释放。
