Battioni J P, Fontecave M, Jaouen M, Mansuy D
Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, CNRS URA 400, Paris, France.
Biochem Biophys Res Commun. 1991 Feb 14;174(3):1103-8. doi: 10.1016/0006-291x(91)91534-j.
Several synthetic Vitamin E derivatives are strong inhibitors of lipid peroxidation induced in rat liver microsomes either chemically by ferrous ions and ascorbate or enzymatically by NADPH and carbon tetrachloride. The relative activities of these inhibitors are consistent with their intrinsic antioxidant properties, as peroxyl radicals scavengers. Among them, a 3,4-dihydro-6-hydroxy-2H-1-naphtopyran with IC50 around 0.08 microM is one of the most potent yet known inhibitor of lipid peroxidation.
几种合成维生素E衍生物是大鼠肝微粒体脂质过氧化的强抑制剂，脂质过氧化可由亚铁离子和抗坏血酸化学诱导，也可由NADPH和四氯化碳酶促诱导。这些抑制剂的相对活性与其作为过氧自由基清除剂的内在抗氧化特性一致。其中，一种IC50约为0.08微摩尔的3,4-二氢-6-羟基-2H-1-萘并吡喃是已知最有效的脂质过氧化抑制剂之一。
