Avril G, Batt M, Guidoin R, Marois M, Hassen-Khodja R, Daune B, Gagliardi J M, Le Bas P
Service de Chirurgie Vasculaire, Hôpital Annexe République, Centre Hospitalier Universitaire, Nice, France.
Ann Vasc Surg. 1991 Jan;5(1):50-4. doi: 10.1007/BF02021778.
To establish possible relationships between the structure of carotid plaque and neurologic symptoms, 187 consecutive endarterectomy specimens were studied prospectively. Each specimen was examined for gross and histopathological features. Intraplaque hemorrhage, although found infrequently, was closely correlated with the presence of symptoms. Plaque ulcerations were encountered more often when lesions were symptomatic. Calcifications were more frequently associated with asymptomatic lesions. Consistency of plaque was related to its morphological features (stenosis or ulceration) and symptoms. Soft plaques with predominant atheromatous grumous material and hemorrhage were associated more often with tightly stenotic, ulcerated, and symptomatic lesions. Consistency of atherosclerotic carotid plaques should be assessed and considered as an important element in the therapeutic decision.
为了确定颈动脉斑块结构与神经症状之间的可能关系，我们对187例连续的动脉内膜切除术标本进行了前瞻性研究。对每个标本进行大体和组织病理学特征检查。斑块内出血虽然很少见，但与症状的出现密切相关。有症状的病变更常出现斑块溃疡。钙化更常与无症状病变相关。斑块的质地与其形态特征（狭窄或溃疡）及症状有关。以粥样凝块物质和出血为主的软斑块更常与严重狭窄、溃疡及有症状的病变相关。应评估动脉粥样硬化性颈动脉斑块的质地，并将其视为治疗决策中的一个重要因素。
