Chamberlain J, Clifford R E, Nathan B E, Price J L, Burn I
J Epidemiol Community Health. 1984 Mar;38(1):54-7. doi: 10.1136/jech.38.1.54.
In a screening service for breast cancer the results of routine repeat tests of women will contribute more than the results of their initial tests. A comparison of first and subsequent screens in a group of high risk women suggests that the sensitivity of screening declines between first and subsequent visits, whereas its specificity improves. Despite improved specificity, the ratio of benign biopsies to cancer was worse at repeated screening (21 to 1) than at first screening (6 to 1). This was because between first and subsequent screens the yield of cancers fell to a greater extent than the yield of benign disease. The patients with breast cancer diagnosed during this study were remarkable for their good prognosis, 92% being still alive and 86% free from recurrence at their last follow up, the follow up intervals ranging from four to eight years.
在一项乳腺癌筛查服务中，女性常规重复检查的结果比初次检查的结果贡献更大。对一组高危女性的首次和后续筛查进行比较表明，筛查的敏感性在首次和后续检查之间下降，而特异性提高。尽管特异性有所提高，但重复筛查时良性活检与癌症的比例（21比1）比首次筛查时（6比1）更差。这是因为在首次和后续筛查之间，癌症的检出率下降幅度大于良性疾病的检出率。在这项研究中被诊断出患有乳腺癌的患者预后良好，值得注意的是，在最后一次随访时，92%的患者仍然存活，86%的患者没有复发，随访间隔为4至8年。
