Butler M G, Haynes J L, Meaney F J
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville.
Clin Genet. 1991 Jan;39(1):39-47. doi: 10.1111/j.1399-0004.1991.tb02983.x.
Age, sex and chromosome effects on weight, height, sitting height, three head dimensions, and five hand and three foot measurements were analyzed from 57 patients (35 males and 22 females) with the Prader-Willi syndrome (PWS). No significant differences were observed in anthropometric data between PWS patients with the 15q chromosome deletion and those with normal chromosomes. Preschool children were found to have dolichocephaly, while hand and foot measurements, stature and sitting height were within normal range, although foot size was smaller than hand size in females when compared with PWS males. However, anthropometric measurements, excluding weight, head length and ankle breadth, were less than -2 SD in adult patients. Abnormal growth patterns apparently exist with significant negative correlations with age, particularly in PWS males, for height, sitting height, head circumference, and hand and foot measurements, but a significant positive correlation for weight was found in patients below 10 years of age.
对57例普拉德-威利综合征（PWS）患者（35例男性和22例女性）的年龄、性别和染色体对体重、身高、坐高、三个头部尺寸以及五项手部和三项足部测量结果的影响进行了分析。15q染色体缺失的PWS患者与染色体正常的患者在人体测量数据上未观察到显著差异。发现学龄前儿童有长头畸形，而手部和足部测量、身高和坐高在正常范围内，不过与PWS男性相比，女性的足尺寸小于手尺寸。然而，成年患者的人体测量值（体重、头长和踝宽除外）小于-2标准差。明显存在异常生长模式，与年龄呈显著负相关，尤其是在PWS男性中，涉及身高、坐高、头围以及手部和足部测量，但10岁以下患者的体重呈显著正相关。
