Effect of indomethacin on opioid-induced gastric protection in cold-restrained stress.
作者信息
Scoto G M, Parenti C, Scoto E, Spadaro C, Arrigo-Reina R
机构信息
Inst. of Pharmacology and Pharmacognosy, Faculty of Pharmacy, Univ. of Catania, Italy.
出版信息
Life Sci. 1991;48(9):867-71. doi: 10.1016/0024-3205(91)90032-7.
PMID:1997788
Abstract
Morphine and the synthetic opioid met-enkephalin analog [D-Ala2, MePhe4, Met(0)5ol] enkephalin (FK 33-824) injected intraperitoneally to rats at doses of 5-20 and 0.5-2 mg/kg respectively showed a protective effect on gastric lesion induced by cold-restraint stress. This protective effect was abolished by pretreatment with indomethacin. This suggests a role for prostaglandins in the protection, induced by opioids of the gastric mucosa against the development of stress-induced ulcers.
摘要
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