Ferri S, Speroni E, Candeletti S, Cavicchini E, Romualdi P, Govoni P, Marchini M
Institute of Pharmacology, University of Bologna, Italy.
Pharmacology. 1988;36(2):140-4. doi: 10.1159/000138371.
The synthetic opioid met-enkephalin analog [D-Ala2, MePhe4, Met(0)5ol] enkephalin (DAMME) and the opiate morphine injected intraperitoneally to rats at doses of 0.5-2 and 5-20 mg/kg, respectively, showed a protective effect on gastric damage induced by oral administration of necrotizing agents (0.6 N HCl or 0.2 N NaOH solutions, 1 ml/rat). The protection was prevented by naltrexone (10 mg/kg s.c.), an opioid antagonist with long-lasting activity. Histological sections of mucosal samples from animals pretreated with morphine (10 mg/kg i.p.) and DAMME (1 mg/kg i.p.) showed less alteration of the columnar epithelium, with a normal glandular structure, than untreated rats. A mediation of prostaglandins is suggested, since indomethacin (10 mg/kg s.c.) significantly reduced the protective effects of opioids.
合成阿片类物质甲硫氨酸脑啡肽类似物[D-丙氨酸2，甲硫苯丙氨酸4，甲硫氨酸(0)5醇]脑啡肽（DAMME）和阿片类药物吗啡分别以0.5 - 2和5 - 20毫克/千克的剂量腹腔注射给大鼠，对口服坏死剂（0.6 N盐酸或0.2 N氢氧化钠溶液，1毫升/只大鼠）诱导的胃损伤显示出保护作用。具有长效活性的阿片类拮抗剂纳曲酮（10毫克/千克皮下注射）可阻止这种保护作用。用吗啡（10毫克/千克腹腔注射）和DAMME（1毫克/千克腹腔注射）预处理的动物的黏膜样本组织学切片显示，与未处理的大鼠相比，柱状上皮的改变较少，腺结构正常。由于吲哚美辛（10毫克/千克皮下注射）显著降低了阿片类药物的保护作用，提示存在前列腺素的介导作用。
