Speroni E, Govoni P, Guizzardi S, Ferri S
Department of Pharmacology, University of Bologna, Italy.
Peptides. 1996;17(6):957-64. doi: 10.1016/0196-9781(96)00138-6.
The effects of a synthetic Met-enkephalin analogue D-Ala2, MePhe4Met(O)5-ol]enkephalin (DAMME) (1 mg/kg. IP) on gastric damage produced by necrotizing agents (0.6 N HCl, ethanol 1 ml/rat, PO) were evaluated, and the correlation between histamine and opioids in stomach was investigated, Rats pretreated with DAMME bad significantly less severe lesions and lower histamine content in gastric tissue. The histamine level, expressed in mg/g of gastric tissue, changed from 0.41 +/- 0.10 of control animals to 1.33 +/- 0.12 for HCl and 1.51 +/- 0.20 for ethanol treatment, whereas in animals pretreated with DAMME the values were significantly reduced to 0.55 +/- 0.13 and 0.65 +/- 0.15. These results confirm a link between the gastroprotection produced by opioids and the modulation of histaminergic activity in the rat stomach.
评估了合成的甲硫氨酸脑啡肽类似物D-Ala2，MePhe4Met(O)5-脑啡肽（DAMME）（1毫克/千克，腹腔注射）对坏死剂（0.6N盐酸，1毫升/大鼠乙醇，经口给药）所致胃损伤的影响，并研究了胃中组胺与阿片类物质之间的相关性。用DAMME预处理的大鼠胃组织损伤明显较轻，组胺含量较低。以毫克/克胃组织表示的组胺水平，对照动物为0.41±0.10，盐酸处理组变为1.33±0.12，乙醇处理组为1.51±0.20，而用DAMME预处理的动物，其值显著降低至0.55±0.13和0.65±0.15。这些结果证实了阿片类物质产生的胃保护作用与大鼠胃中组胺能活性调节之间的联系。
