Spadaro C, Arrigo-Reina R, Scoto G M
Pharmacol Res Commun. 1987 Mar;19(3):223-30. doi: 10.1016/0031-6989(87)90065-8.
The effects of morphine HCl and a synthetic met-enkephalin analogue [D-Ala2,MePhe4,Met(O)5ol]enkephalin (FK 33-824) on gastric damage produced by the intraperitoneal administration of indomethacin (10 mg/kg i.p.) have been investigated. Rats intraperitoneally pretreated with morphine HCl (10 mg/kg i.p.) and FK 33-824 (1 mg/kg i.p.) showed a statistically significant reduction both of the number and intensity of lesions induced by indomethacin. This protection was reversed by naloxone HCl (2 mg/kg i.p.). The protective effect was not related to a reduction of gastric secretion since the antisecretory drug cimetidine (25 mg/kg i.p.) and methscopolamine bromide (10 mg/kg i.p.) did not significantly prevent mucosal damage under the same experimental conditions.
研究了盐酸吗啡和一种合成的甲硫氨酸脑啡肽类似物[D-丙氨酸²，甲硫苯丙氨酸⁴，甲硫氨酸（氧代）⁵]脑啡肽（FK 33-824）对腹腔注射吲哚美辛（10毫克/千克腹腔注射）所致胃损伤的影响。预先腹腔注射盐酸吗啡（10毫克/千克腹腔注射）和FK 33-824（1毫克/千克腹腔注射）的大鼠，吲哚美辛诱导的损伤数量和强度均有统计学意义的显著降低。盐酸纳洛酮（2毫克/千克腹腔注射）可逆转这种保护作用。该保护作用与胃分泌减少无关，因为在相同实验条件下，抗分泌药物西咪替丁（25毫克/千克腹腔注射）和溴甲东莨菪碱（10毫克/千克腹腔注射）并不能显著预防黏膜损伤。
