Dworkin B M, Chodos J E, Fernandez M E, Van Horn K, Cabello F, Wormser G P
Sarah C. Upham Division of Gastroenterology, New York Medical College, Valhalla.
Am J Gastroenterol. 1991 Mar;86(3):354-6.
Plasmids may effect bacterial virulence and antibiotic resistance, and serve as epidemiologic markers. In this study, plasmid DNA profiles of serial isolates of Helicobacter pylori showed persistence of an identical strain of this organism in a patient with duodenal ulcer disease. Three control strains of H. pylori isolated from other patients contained plasmids different from each other and from that of the original patient; two of these strains had two plasmids each. These data have important implications for further study of the epidemiology and pathogenesis of H. pylori-related diseases.
质粒可能影响细菌的毒力和抗生素耐药性，并可作为流行病学标志物。在本研究中，十二指肠溃疡病患者幽门螺杆菌系列分离株的质粒DNA图谱显示，该菌的同一菌株持续存在。从其他患者分离出的3株幽门螺杆菌对照菌株所含质粒彼此不同，也与原患者的质粒不同；其中两株菌株各有两个质粒。这些数据对进一步研究幽门螺杆菌相关疾病的流行病学和发病机制具有重要意义。
