Hoffmann D, Djordjevic M V, Brunnemann K D
American Health Foundation, Valhalla, NY 10595.
Food Chem Toxicol. 1991 Jan;29(1):65-8. doi: 10.1016/0278-6915(91)90064-e.
Snuff dipping is causally related to cancer of the oral cavity and pharynx. The most powerful carcinogens in snuff are nitroso compounds, particularly the tobacco-specific N-nitrosamines (TSNA). Concentrations of TSNA in snuff exceed the known concentrations of carcinogenic nitrosamines in any other consumer product by two to three orders of magnitude. During the last decade a gradual decrease in TSNA has occurred in the two leading snuff brands in the USA (about 90% of the market). Of two recently introduced snuff brands one has relatively low levels of nitroso compounds while the other contains the highest concentrations of nitrosamines ever reported in smokeless tobacco. This observation suggests that control of nitrosamines in snuff brands on the US market is desirable.
嚼鼻烟与口腔癌和咽癌存在因果关系。鼻烟中最强大的致癌物是亚硝基化合物，尤其是烟草特有的N-亚硝胺（TSNA）。鼻烟中TSNA的浓度比任何其他消费品中已知的致癌亚硝胺浓度高出两到三个数量级。在过去十年中，美国两个领先的鼻烟品牌（约占市场的90%）中的TSNA含量逐渐下降。在最近推出的两个鼻烟品牌中，一个品牌的亚硝基化合物含量相对较低，而另一个品牌含有无烟烟草中报道过的最高浓度的亚硝胺。这一观察结果表明，对美国市场上鼻烟品牌中的亚硝胺进行管控是有必要的。
