在基瓦姆烟草中N-亚硝基化合物的存在情况。

The occurrence of N-nitroso compounds in kiwam tobacco.

作者信息

Tricker A R, Preussmann R

机构信息

Institute of Toxicology and Chemotherapy, German Cancer Research Center, Heidelberg.

出版信息

Cancer Lett. 1989 Aug;46(3):221-4. doi: 10.1016/0304-3835(89)90134-1.

DOI:10.1016/0304-3835(89)90134-1

PMID:2766262

Abstract

The concentrations of tobacco-specific nitrosamines (TSNA), volatile and non-volatile N-nitroso compounds in kiwam, a fermented Indian tobacco product are presented. Total identified N-nitroso compound concentrations in kiwam ranged from 6.19 to 25.4 mg/kg fresh weight tobacco, the concentration range of TSNA was 5.43-22.2 mg/kg tobacco which accounted for 67-87% of the total identified N-nitroso compound burden. The high concentrations of TSNA found in kiwam tobacco may present a considerable exposure source to carcinogenic N-nitroso compounds for people using this type of tobacco.

摘要

本文给出了印度发酵烟草制品奇瓦姆（kiwam）中烟草特有亚硝胺（TSNA）、挥发性和非挥发性N-亚硝基化合物的浓度。奇瓦姆中已鉴定出的N-亚硝基化合物总浓度在6.19至25.4毫克/千克鲜重烟草之间，TSNA的浓度范围为5.43 - 22.2毫克/千克烟草，占已鉴定出的N-亚硝基化合物总量的67 - 87%。在奇瓦姆烟草中发现的高浓度TSNA可能会给使用这类烟草的人带来相当大的致癌N-亚硝基化合物暴露源。