Department of Radiological Science, King Saud University, Kharj, Saudi Arabia.
J Immunotoxicol. 2010 Mar;7(1):68-75. doi: 10.3109/15476910903409835.
Myrrh (Commiphora molmol) has been widely used as an anti-inflammatory and wound healing commercial product. As white blood cell (WBC)/leukocyte counts have been used as an indicator by clinicians to monitor progress of healing in patients, the purpose of this study was to examine effects of myrrh supplementation on blood WBC numbers before an injury and during healing. Male rats (7-8-wk-of-age) were randomly assigned to four groups. Group 1 (SIM) served as "skin injury treated + myrrh treatment (500 mg/kg/day)," Group 2 (SI) as "skin injury alone", Group 3 (GUM) as "gastric ulcer treated + myrrh treatment", and Group 4 (GU) as gastric ulcer only. Myrrh treatments (via drinking water) began 4 wk before induction of injury and continued for a 2 wk period post-injury. Baseline values for each WBC type were recorded before start of the myrrh treatments. Counts were performed again on Day 1 of the 5th wk (1-2 hr before injury) and post-injury on Days 4 and 7 of the 5th wk, and a final time on Day 4 of the 6th wk. Results showed that levels of all WBC types were significantly (P < 0.05) elevated before either injury in myrrh-treated rats (Groups 1 and 3) as compared with levels in rats in Groups 2 and 4. At all timepoints, there were neither significant differences between the values seen with rats in Groups 1 and 3, nor between those in Groups 2 and 4. Treatment with myrrh also induced an initial increase in WBC levels that persisted through the post-injury healing period. Levels of most cell types only increased in the Group 2 and 4 rats once the injury was induced, but then declined over the healing period. Since myrrh enhanced WBC levels before injury, we conclude that myrrh likely contains substances that could induce an apparent antigen-driven response. As the myrrh also helped maintain elevated WBC levels throughout the healing period, this implied it was also able to induce maturation/differentiation/activation of both myeloid and lymphoid cell types during the effector phase of the immune responses involved in wound healing.
没药（Commiphora molmol）被广泛用作一种具有抗炎和促进伤口愈合作用的商业产品。由于白细胞（WBC）/白细胞计数已被临床医生用作监测患者愈合进展的指标，因此本研究旨在检查没药补充剂对受伤前和愈合期间血液 WBC 数量的影响。雄性大鼠（7-8 周龄）被随机分为四组。第 1 组（SIM）作为“皮肤损伤治疗+没药治疗（500mg/kg/天）”，第 2 组（SI）作为“单纯皮肤损伤”，第 3 组（GUM）作为“胃溃疡治疗+没药治疗”，第 4 组（GU）作为单纯胃溃疡。没药治疗（通过饮用水）在诱导损伤前 4 周开始，并在损伤后继续进行 2 周。在开始没药治疗前记录每种 WBC 类型的基线值。在第 5 周的第 1 天（受伤前 1-2 小时）再次进行计数，并在第 5 周的第 4 天和第 7 天进行受伤后计数，最后在第 6 周的第 4 天进行计数。结果表明，与第 2 组和第 4 组大鼠相比，在第 1 组和第 3 组大鼠中，所有 WBC 类型的水平在受伤前均显著（P <0.05）升高。在所有时间点，第 1 组和第 3 组大鼠之间的数值以及第 2 组和第 4 组大鼠之间的数值均无显著差异。没药治疗还诱导了 WBC 水平的初始升高，并持续到受伤后的愈合期。只有在第 2 组和第 4 组大鼠受伤后，大多数细胞类型的水平才会升高，但随后在愈合期间下降。由于没药在受伤前增强了 WBC 水平，我们得出结论，没药可能含有能诱导明显抗原驱动反应的物质。由于没药还能帮助维持整个愈合期升高的 WBC 水平，这意味着它还能够在参与伤口愈合的免疫反应的效应阶段诱导骨髓和淋巴样细胞类型的成熟/分化/激活。
