Saaka Mahama, Oosthuizen Jacques, Beatty Shelley
Edith Cowan University, School of Exercise, Biomedical and Health Sciences, Joondalup, WA 6027, Australia.
East Afr J Public Health. 2009 Apr;6(1):55-62. doi: 10.4314/eajph.v6i1.45748.
In spite of interventions being put in place to reduce the burden of maternal anaemia and malaria in Ghana, they continue to impact negatively on pregnancy outcomes. It is unclear whether there are some other factors that limit the effectiveness of these interventions. The aim of this study was to explore whether there are benefits associated with the addition of zinc to the routine malaria chemoprophylaxis, iron and folic acid intervention package for pregnant women in Ghana.
A double-blind, randomised controlled trial (RCT) conducted in the Upper West Region of Ghana.
Iron-zinc supplementation reduced the risk of increased malaria parasitaemia associated with high maternal serum ferritin and Hb concentrations. Iron-zinc supplementation was associated with reduced malaria parasite densities, F (1, 20) = 4.744, p = 0.042. Iron and zinc provided in the ratio of 1:1 prevented a significant decline in maternal iron stores of pregnant women. Adjusted geometric mean serum ferritin concentration in the Iron-zinc Group was significantly higher than in the Control Group (22.9 microg/L versus 16.9 microg/L), F (1, 156)= 6.336, p = 0.013
Joint iron and zinc supplementation appears to be a better option than iron-only supplementation in malaria-endemic areas.
尽管加纳已采取干预措施以减轻孕产妇贫血和疟疾负担，但这些问题仍对妊娠结局产生负面影响。尚不清楚是否存在其他因素限制了这些干预措施的效果。本研究的目的是探讨在加纳孕妇常规疟疾化学预防、铁和叶酸干预方案中添加锌是否有益。
在加纳上西部地区进行的一项双盲随机对照试验（RCT）。
铁锌补充剂降低了与高母体血清铁蛋白和血红蛋白浓度相关的疟疾寄生虫血症增加的风险。铁锌补充剂与降低疟原虫密度有关，F（1, 20）= 4.744，p = 0.042。以1:1比例提供的铁和锌可防止孕妇母体铁储备显著下降。铁锌组调整后的几何平均血清铁蛋白浓度显著高于对照组（22.9微克/升对16.9微克/升），F（1, 156）= 6.336，p = 0.013
在疟疾流行地区，联合补充铁和锌似乎比单纯补充铁是更好的选择。
