State Key Laboratory of Organic Geochemistry, Guangdong Key Laboratory of Environment Protection and Resources Utilization, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China.
Environ Sci Technol. 2009 Dec 15;43(24):9453-7. doi: 10.1021/es901672m.
Previous studies have reported high serum concentrations of polybrominated diphenyl ethers in residents of an electronic waste (e-waste) dismantling site in Guiyu town, South China. In this study, serum levels of Dechlorane Plus (DP), a chlorinated flame retardant of growing concern, were measured in residents of this region, and compared to those of a matched cohort from a nearby region in Haojiang, where fishing is the dominant industry. DP was detected in all the serum samples, with concentrations ranging from 7.8 to 465 ng/g lipid (median: 42.6 ng/g) and 0.93 to 50.5 ng/g lipid (median: 13.7 ng/g) in Guiyu and Haojiang, respectively. The Pearson's correlation coefficient between DP and decabromodiphenyl ether showed a positive relationship in Guiyu (r = 0.931, p < 0.01), but no correlation in Haojiang (r = 0.321, p = 0.34). The average anti-DP fractional abundances (f(anti) ratio) were 0.58 +/- 0.11 and 0.64 +/- 0.05 for Guiyu and Haojiang, respectively (p < 0.01). Tentatively identified dechlorination product ([-Cl + H]) was found in 19/40 serum samples (11/20 for Guiyu, 8/20 for Haojiang). These results suggest that the Guiyu and Haojiang cohorts experienced different dominant exposure routes. It is also possible that DP could bioaccumulate in a stereoselective manner, and undergo dechlorination metabolism. To the best of our knowledge, this is the first study to report DP levels in human serum. Further studies are needed to confirm the results of this study.
先前的研究报告称，中国南方贵屿镇电子废物（电子垃圾）拆解场的居民血清中多溴联苯醚浓度较高。在这项研究中，测量了该地区居民血清中氯化阻燃剂十溴二苯醚（DP）的水平，并与来自附近豪江地区的匹配队列进行了比较，豪江地区的主导产业是渔业。DP 存在于所有血清样本中，贵屿和豪江血清中的浓度范围分别为 7.8 至 465ng/g 脂质（中位数：42.6ng/g）和 0.93 至 50.5ng/g 脂质（中位数：13.7ng/g）。DP 与十溴联苯醚之间的 Pearson 相关系数在贵屿呈正相关（r = 0.931，p < 0.01），但在豪江无相关性（r = 0.321，p = 0.34）。贵屿和豪江的平均抗 DP 分数丰度（f(anti)比值）分别为 0.58 +/- 0.11 和 0.64 +/- 0.05（p < 0.01）。在 19/40 份血清样本（贵屿 11/20，豪江 8/20）中发现了暂定的脱氯产物（[-Cl + H]）。这些结果表明，贵屿和豪江两组人群经历了不同的主要暴露途径。也有可能 DP 以立体选择性的方式生物累积，并经历脱氯代谢。据我们所知，这是首次报道人血清中 DP 水平的研究。需要进一步的研究来证实本研究的结果。
