奥地利山萝卜中的倍半萜内酯。

Sesquiterpene lactones from Scorzonera austriaca.

机构信息

State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, and Radiochemistry Laboratory, Lanzhou University, Lanzhou 730000, People's Republic of China.

出版信息

J Nat Prod. 2010 Feb 26;73(2):237-41. doi: 10.1021/np900378c.

DOI:10.1021/np900378c

PMID:20148526

Abstract

Six new sesquiterpene lactones, scorzoaustriacoside (1), scorzoaustriacin (2), scorzoaustriacin 3-O-beta-d-glucoside (3), 4-epi-dihydroestafiatol (4), 14-isovaleroxyscorzoaustricin (5), and 14-isovaleroxyscorzoaustricin sulfate (6), along with five known guaianolides, were isolated from an acetone extract of the roots of Scorzonera austriaca. The structures of the new compounds were elucidated mainly by interpretation of their 1D and 2D NMR and HRMS data. Several isolates obtained in this investigation were evaluated against a small panel of cancer cell lines.

摘要

从 Scorzonera austriaca 的根的丙酮提取物中分离得到了六种新的倍半萜内酯，分别为 scorzoaustriacoside（1）、scorzoaustriacin（2）、scorzoaustriacin 3-O-β-d-葡萄糖苷（3）、4-epi-dihydroestafiatol（4）、14-异戊酰氧基角鲨烯（5）和 14-异戊酰氧基角鲨烯硫酸盐（6）。此外，还从该研究中获得了几种分离物，并对其进行了评估，以评估它们对一组小型癌细胞系的抑制作用。