Department of Histopathology, St. James' University Hospital, Leeds, West Yorkshire, United Kingdom.
Pathology. 2009;41(7):645-8. doi: 10.3109/00313020903273084.
To establish the prognosis associated with female adnexal tumour of probable wolffian origin (FATWO) and determine the frequency with which it behaves as a truly benign lesion.
Medline and Embase electronic databases were interrogated to identify 31 papers describing 63 patients with FATWO with follow up.
Fifty (79%, CI 67.4-87.3%) were alive and well but seven patients had recurrent or residual disease (11.1%, CI 5.6-21.5%) and three had died of disease (4.8%, CI 1.6-13.1%). Stage (p = 0.0002) and differentiation (p = 0.0118) showed a significant association with outcome although atypia approached significance at the 5% level (p = 0.0658). One patient with a ruptured tumour had recurrent disease and one other had died of disease (p = 0.2278). There was no association between outcome and age (p = 0.6651), size (p = 0.1912), length of survival (p = 0.2351) tumour site, mitotic rate or necrosis (p = 0.5937, 0.4697 and 0.2016, respectively).
On the basis of these findings, FATWO cannot be regarded as a benign lesion. These lesions may be confused with well differentiated gynaecological cancers and careful clinicopathological correlation with the extensive use of immunohistochemistry is encouraged to ensure that lesions such as extragonadal endometrioid adenocarcinoma is not confused with FATWO.
确定女性附件可能来源于 Wolffian 组织的肿瘤（FATWO）的预后，并确定其表现为真正良性病变的频率。
通过 Medline 和 Embase 电子数据库检索了 31 篇描述了 63 例具有 FATWO 并随访的患者的论文。
50 例（79%，CI 67.4-87.3%）存活且情况良好，但 7 例患者有复发或残留疾病（11.1%，CI 5.6-21.5%），3 例患者死于疾病（4.8%，CI 1.6-13.1%）。分期（p=0.0002）和分化（p=0.0118）与预后显著相关，尽管不典型性在 5%水平接近显著（p=0.0658）。1 例破裂肿瘤患者有复发疾病，另 1 例患者死于疾病（p=0.2278）。预后与年龄（p=0.6651）、大小（p=0.1912）、生存时间（p=0.2351）、肿瘤部位、有丝分裂率或坏死（p=0.5937、0.4697 和 0.2016）无关。
根据这些发现，FATWO 不能被视为良性病变。这些病变可能与分化良好的妇科癌症混淆，鼓励仔细的临床病理相关性，并广泛使用免疫组织化学，以确保不会将诸如卵巢外子宫内膜样腺癌与 FATWO 混淆。
