与肌动蛋白细胞骨架调节改变相关的免疫病理学。
Immune pathology associated with altered actin cytoskeleton regulation.
机构信息
Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
出版信息
Autoimmunity. 2010 Feb;43(1):64-75. doi: 10.3109/08916930903374634.
Abstract
The actin cytoskeleton plays a crucial role in a variety of important cellular processes required for normal immune function, including locomotion, intercellular interactions, endocytosis, cytokinesis, signal transduction, and maintenance of cell morphology. Recent studies have uncovered not only many of the components and mechanisms that regulate the cortical actin cytoskeleton but have also revealed significant immunopathological consequences associated with genetic alteration of actin cytoskeletal regulatory genes. These advances have provided new insights into the role of cortical actin cytoskeletal regulation in a number of immune cell functions and have identified cytoskeletal regulatory proteins critical for normal immune system activity and susceptibility to autoimmunity.
摘要
肌动蛋白细胞骨架在正常免疫功能所需的各种重要细胞过程中起着至关重要的作用，包括运动、细胞间相互作用、内吞作用、胞质分裂、信号转导和维持细胞形态。最近的研究不仅揭示了调节皮质肌动蛋白细胞骨架的许多成分和机制，还揭示了与肌动蛋白细胞骨架调节基因遗传改变相关的重要免疫病理后果。这些进展为皮质肌动蛋白细胞骨架调节在许多免疫细胞功能中的作用提供了新的见解，并确定了对正常免疫系统功能和自身免疫易感性至关重要的细胞骨架调节蛋白。
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