University Hospital Llandough, Department of Diabetes & Endocrinology, Llandough, CF64 2XX, Cardiff, UK.
Expert Opin Pharmacother. 2010 Jan;11(1):33-9. doi: 10.1517/14656560903393769.
Postprandial hyperglycaemia is becoming topical, with studies suggesting a link to cardiovascular disease. Recently, a number of new therapies for the treatment of type 2 diabetes have become available.
This review looks at the evidence for the potential role of insulin analogue mix 50 to reduce postprandial hyperglycaemia and cardiovascular disease.
Medline and Embase databases were searched using the MeSH terms to identify relevant studies from 1980 to 2009. Both original articles and reviews were extracted. Published reference lists were also examined. MeSH terms used for literature searching: human insulins, insulin analogues, insulin analogue mix 50, glycaemia, postprandial glucose, fasting glucose, type 2 diabetes, type 1 diabetes, cardiovascular disease.
The reader is presented with evidence discussing the importance of postprandial hyperglycaemia and studies comparing different insulin regimes and in particular insulin analogue mix 50 and its potential to reduce postprandial glucose surges and reduce cardiovascular disease.
TAKE-HOME MESSAGE: Insulin analogue mix 50 is a viable therapeutic option in a sub-group of patients with type 2 diabetes.
餐后高血糖症日益受到关注，有研究表明其与心血管疾病有关。最近，一些新的治疗 2 型糖尿病的疗法已经问世。
本篇综述着眼于胰岛素类似物混合 50 降低餐后高血糖症和心血管疾病潜在作用的证据。
使用 MeSH 术语搜索 Medline 和 Embase 数据库，以确定从 1980 年到 2009 年的相关研究。提取了原始文章和综述。还检查了已发表的参考文献列表。用于文献搜索的 MeSH 术语：人胰岛素、胰岛素类似物、胰岛素类似物混合 50、血糖、餐后血糖、空腹血糖、2 型糖尿病、1 型糖尿病、心血管疾病。
读者将获得有关餐后高血糖症重要性的证据，并比较不同胰岛素方案的研究，特别是胰岛素类似物混合 50 及其降低餐后血糖波动和降低心血管疾病的潜力。
胰岛素类似物混合 50 是 2 型糖尿病亚组患者的一种可行的治疗选择。
