Santacroce Luigi, Carlaio Roberto Gianfranco, Bottalico Lucrezia
Department of Internal Medicine, Immunology and Infectious Diseases, University Hospital, Italy.
Endocr Metab Immune Disord Drug Targets. 2010 Mar;10(1):57-70. doi: 10.2174/187153010790827975.
Epidemiological studies indicated that more than 15% of the population in western countries suffer because of severe forms of periodontitis, In this respect, the recognition of the relationship between oral and systemic health is growing, thus receiving remarkable interest in scientific literature. In fact, periodontitis may increase the risk for a group of life-threatening conditions such as atherosclerosis, stroke or low birth weight. The American Diabetes Association has reported that individuals with uncontrolled diabetes (defined as 200mg/dL of glucose on three consecutive readings) undergo an increased risk of infections, abnormal wound healing and consequent increased recovery time. Moreover, diabetics may be more likely to develop periodontal and cardiovascular disease than non diabetics, if note. History of poorly controlled chronic periodontal disease can alter diabetic/glycemic control. This may originate from a likely continuous passege of bacterial toxins and/or bacteria into the bloodstream, and/or from an exaggerated release of inflammatory mediators. This review is aimed at elucidating the connections between the status of oral health and glycemic control in diabetes.
流行病学研究表明，西方国家超过15%的人口因严重形式的牙周炎而受苦。在这方面，对口腔健康与全身健康之间关系的认识正在不断提高，因此在科学文献中受到了显著关注。事实上，牙周炎可能会增加患一系列危及生命疾病的风险，如动脉粥样硬化、中风或低出生体重。美国糖尿病协会报告称，糖尿病未得到控制的个体（定义为连续三次血糖读数达到200mg/dL）发生感染、伤口愈合异常以及恢复时间随之增加的风险会升高。此外，如果不考虑其他因素，糖尿病患者比非糖尿病患者更有可能患牙周病和心血管疾病。慢性牙周病控制不佳的病史会改变糖尿病/血糖控制情况。这可能源于细菌毒素和/或细菌可能持续进入血液，和/或源于炎症介质的过度释放。这篇综述旨在阐明糖尿病患者口腔健康状况与血糖控制之间的联系。
