Institute of Immunobiology and Human Genetics, Faculty of Medicine, 1109 Skopje, PO Box 60, Macedonia.
Bosn J Basic Med Sci. 2009 Nov;9(4):283-9. doi: 10.17305/bjbms.2009.2780.
Autistic disorder is a severe neurodevelopment disorder characterized by a triad of impairments in reciprocal social interaction, verbal and nonverbal communication, and a pattern of repetitive stereotyped activities, behaviours and interests. There are strong lines of evidence to suggest that the immune system plays an important role in the pathogenesis of autistic disorder. The aim of this study was to analyze quantitative plasma concentration of immunoglobulin classes, and subclasses in autistic patients and their families. The investigation was performed retrospectively in 50 persons with autistic disorder in the Republic of Macedonia. Infantile autistic disorder was diagnosed by DSM-IV and ICD-10 criteria. Plasma immunoglobulin classes (IgM, IgA, and IgG) and subclasses (IgG1, IgG2, IgG3, and IgG4) were determined using Nephelometer Analyzer BN-100. Multiple comparisons for the IgA variable have shown statistically significant differences between three pairs: male autistic from the fathers (p = 0,001), female autistic from the mothers (p = 0,008), as well as healthy sisters from the fathers (p = 0,011). Statistically significant differences found between three groups regarding autistic disorder (person with autistic disorder, father/mother of a person with autistic disorder, and brother/sister) independent of sex belongs to IgA, IgG2, and IgG3 variables. Multiple comparisons for the IgA variable have shown statistically significant differences between children with autistic disorder from the fathers and mothers (p < 0,001), and healthy brothers and sisters from the fathers and mothers (p < 0,001). Comparison between healthy children and children with autistic disorder from the same family should be tested for immunoglobulin classes and subclasses in order to avoid differences between generations.
自闭症是一种严重的神经发育障碍，其特征是在相互社交互动、言语和非言语交流以及重复刻板的活动、行为和兴趣模式方面存在三重障碍。有强有力的证据表明免疫系统在自闭症的发病机制中起着重要作用。本研究的目的是分析自闭症患者及其家属的免疫球蛋白类别和亚类的定量血浆浓度。该研究在马其顿共和国对 50 名自闭症患者进行了回顾性分析。婴儿自闭症是根据 DSM-IV 和 ICD-10 标准诊断的。使用 Nephelometer Analyzer BN-100 测定血浆免疫球蛋白类别（IgM、IgA 和 IgG）和亚类（IgG1、IgG2、IgG3 和 IgG4）。对 IgA 变量的多次比较表明，三组之间存在统计学上的显著差异：来自父亲的男性自闭症患者（p = 0.001）、来自母亲的女性自闭症患者（p = 0.008）以及来自父亲的健康姐妹（p = 0.011）。关于自闭症（自闭症患者、自闭症患者的父母、兄弟姐妹）的三组之间存在统计学显著差异，与性别无关，属于 IgA、IgG2 和 IgG3 变量。对 IgA 变量的多次比较表明，自闭症儿童与父母（p < 0.001）以及与父母的健康兄弟姐妹（p < 0.001）之间存在统计学显著差异。为了避免代际差异，应检测同一家族的健康儿童和自闭症儿童的免疫球蛋白类别和亚类。
