帕金森病患者的脑脊液代谢物与黑质纹状体多巴胺能功能。
Cerebrospinal fluid metabolite and nigrostriatal dopaminergic function in Parkinson's disease.
机构信息
Department of Neurology and Neurological Science, Tokyo Medical and Dental University, Japan.
出版信息
Acta Neurol Scand. 2010 Jul;122(1):46-51. doi: 10.1111/j.1600-0404.2009.01255.x. Epub 2009 Nov 28.
OBJECTIVES
To evaluate the association between cerebrospinal fluid (CSF) homovanillic acid (HVA) concentrations and nigrostriatal dopaminergic function assessed by positron emission tomography (PET) imaging with carbon-11-labeled 2beta-carbomethoxy-3beta-(4-fluorophenyl)-tropane ((11)C-CFT), which can measure the dopamine transporter (DAT) density, in Parkinson's disease (PD).
METHODS
(11)C-CFT PET scans and CSF examinations were performed on 21 patients with PD, and six patients with non-parkinsonian syndromes (NPS) as a control group.
RESULTS
In the PD group, CSF HVA concentrations were significantly correlated with the striatal uptake of (11)C-CFT (r = 0.76, P < 0.01). However, in the NPS group, two indices were within the normal range.
CONCLUSIONS
In PD, CSF HVA concentrations correlate with nigrostriatal dopaminergic function. Therefore, CSF HVA concentrations may be an additional surrogate marker for estimating the remaining nigrostriatal dopaminergic function in case that DAT imaging is unavailable.
目的
评估帕金森病（PD）患者脑脊液（CSF）高香草酸（HVA）浓度与正电子发射断层扫描（PET）成像用碳-11 标记的 2β- 碳甲氧基-3β-（4-氟苯基）-托烷（11C-CFT）评估的黑质纹状体多巴胺能功能之间的相关性，11C-CFT 可测量多巴胺转运体（DAT）密度。
方法
对 21 例 PD 患者和 6 例非帕金森综合征（NPS）患者进行 11C-CFT PET 扫描和 CSF 检查。
结果
在 PD 组中，CSF HVA 浓度与纹状体摄取 11C-CFT 呈显著相关（r = 0.76，P < 0.01）。然而，在 NPS 组中，两个指标均在正常范围内。
结论
在 PD 中，CSF HVA 浓度与黑质纹状体多巴胺能功能相关。因此，在无法进行 DAT 成像的情况下，CSF HVA 浓度可能是评估剩余黑质纹状体多巴胺能功能的另一个替代标志物。
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