在未经药物治疗的帕金森病患者的心肌闪烁显像期间，脑脊液 5-HIAA 浓度与 I-MIBG 的心脏摄取呈正相关。
Cerebrospinal fluid 5-HIAA concentrations correlate with cardiac uptake of I-MIBG during myocardial scintigraphy in drug naïve Parkinson's disease.
机构信息
Department of Neurology, School of Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
出版信息
J Neural Transm (Vienna). 2018 Oct;125(10):1511-1514. doi: 10.1007/s00702-018-1917-x. Epub 2018 Aug 23.
We examined the correlations between cerebrospinal fluid (CSF) concentrations of homovanillic acid (HVA) and 5-hydroxyindole acetic acid (5-HIAA) and imaging assessment scores, using I-Ioflupane SPECT and I-MIBG myocardial scintigraphy in 23 drug naïve PD patients. The CSF 5-HIAA concentration correlated with the H/M ratio of the delayed image (r = 0.458, p < 0.05) and the washout rate (r = - 0.642, p < 0.01) of I-MIBG myocardial scintigraphy. These correlations suggest some unclarified pathophysiological links between the central serotonergic and cardiac sympathetic systems.
我们研究了 23 例未经药物治疗的帕金森病患者的脑脊液（CSF）高香草酸（HVA）和 5-羟吲哚乙酸（5-HIAA）浓度与 I-碘代异丙基安非他命 SPECT 和 I-间碘苄胍心肌闪烁显像评估分数之间的相关性。CSF 5-HIAA 浓度与 I-MIBG 心肌闪烁显像的延迟图像 H/M 比值（r = 0.458，p < 0.05）和洗脱率（r = -0.642，p < 0.01）相关。这些相关性提示中枢 5-羟色胺能和心脏交感神经系统之间存在一些未阐明的病理生理联系。
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