中国青海高原老年人综合老年评估 II：三种民族中红细胞增多症与生活方式相关疾病的关系。

Comprehensive geriatric assessment of elderly highlanders in Qinghai, China II: the association of polycythemia with lifestyle-related diseases among the three ethnicities.

机构信息

Research Institute for Humanity and Nature, 457-4 Motoyama, Kamigamo, Kita-ku, Kyoto 603-8047, Japan.

出版信息

Geriatr Gerontol Int. 2009 Dec;9(4):342-51. doi: 10.1111/j.1447-0594.2009.00555.x.

DOI:10.1111/j.1447-0594.2009.00555.x

PMID:20002753

Abstract

AIM

The objective of this study is to disclose the association of polycythemia with lifestyle-related diseases (hypertension, obesity and glucose intolerance) among the three ethnicities in Qinghai, China.

METHODS

The subjects were 393 elderly people (247 Han, 97 Tibetan and 49 Mongolian) aged 60 years and more living in Qinghai (3000 m a.s.l.) in China. The associated factors with polycythemia were analyzed in the subjects. Excessive polycythemia was defined as hemoglobin concentration over 20 mg/dL.

RESULTS

Polycythemia was associated with men, hypoxemia, obesity and high diastolic blood pressure (DBP) in the elderly in Qinghai. Male sex was associated with polycythemia in all ethnicities. Obesity was associated with Han and Tibetan men. Glucose intolerance and activities of daily living were not directly associated with polycythemia after adjustment for sex. There were 7.9% with excessive polycythemia. Independently-associated factors for excessive polycythemia were male sex, body mass index of 25 or more, SpO(2) of less than 85%, DBP of 85 mmHg or more and Han ethnicity (vs Tibetan) by multiple logistic regression.

CONCLUSION

There was a close association of polycythemia with diastolic hypertension and obesity in lifestyle-related diseases in high-altitude elderly people. Han people had a higher hemoglobin concentration after adjustment of lifestyle-related diseases compared with Tibetan people. The difference of hemoglobin concentration may be due to Tibetans undergoing a much longer period of adaptation than Han people. Further study is needed to disclose the association between the difference of hypoxic adaptation, lifestyle-related diseases and chronic mountain sickness for their prevention.

摘要

目的

本研究旨在揭示中国青海三种人群中与生活方式相关疾病（高血压、肥胖和葡萄糖不耐受）相关的红细胞增多症的关联。

方法

研究对象为居住在中国青海（海拔 3000 米）的 393 名 60 岁及以上的老年人（247 名汉族、97 名藏族和 49 名蒙古族）。分析了与红细胞增多症相关的因素。血红蛋白浓度超过 20mg/dL 被定义为红细胞增多过多。

结果

红细胞增多症与青海老年人中的男性、低氧血症、肥胖和舒张压（DBP）升高有关。男性在所有民族中都与红细胞增多症有关。肥胖与汉族和藏族男性有关。葡萄糖不耐受和日常生活活动与性别调整后与红细胞增多症并无直接关联。红细胞增多过多的比例为 7.9%。男性、体重指数 25 或以上、SpO2 低于 85%、DBP 为 85mmHg 或更高以及汉族（与藏族相比）是红细胞增多过多的独立相关因素。