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中国东南部地区结核病患者 Toll 样受体 2 和 4 基因多态性研究。

Toll-like receptors 2 and 4 gene polymorphisms in a southeastern Chinese population with tuberculosis.

机构信息

Institute of Cell Biology, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China.

出版信息

Int J Immunogenet. 2010 Apr;37(2):135-8. doi: 10.1111/j.1744-313X.2009.00892.x. Epub 2009 Dec 3.

DOI:10.1111/j.1744-313X.2009.00892.x
PMID:20002809
Abstract

Polymorphisms of the toll-like receptor 2 (TLR2) gene (Arg677Trp, Arg753Gln) and the TLR4 gene (Asp299Gly, Thr399Ile) were investigated in 205 tuberculosis (TB) patients and 203 controls. Genetic variations were analysed by DNA sequencing. We revealed that these polymorphisms were rare in the southeastern Chinese population and were not associated with susceptibility to TB.

摘要

研究了 205 例肺结核（TB）患者和 203 例对照者的 toll 样受体 2（TLR2）基因（Arg677Trp、Arg753Gln）和 TLR4 基因（Asp299Gly、Thr399Ile）的多态性。通过 DNA 测序分析遗传变异。我们揭示了这些多态性在东南中国人群中很少见，与 TB 的易感性无关。

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