Heukelbach Jorg, Asenov André, Liesenfeld Oliver, Mirmohammadsadegh Ali, Oliveira Fabíola A
Department of Community Health, Federal University of Ceará, Costa Mendes, Fortaleza CE, Brazil.
BMC Dermatol. 2009 Dec 14;9:12. doi: 10.1186/1471-5945-9-12.
Dimeticones kill head lice by physical means. Here we assessed in a comparative bioassay the ex vivo efficacy of "NYDA sensitiv", a new two-phase dimeticone-based pediculicide similar to a product established on the market, but without fragrances.
We compared efficacy of the new product to a positive dimeticone control group, a sample of four other insecticidal and natural head lice products marketed in Germany, and an untreated control. In a bioassay, lice were exposed ex vivo to products and examined for activity for up to 24 hours, following a standard protocol.
After 6 and 24 hours, 13.7 and 88.5% of untreated control lice did not show major vital signs. In contrast, no lice showed major vital signs 5 minutes after treatment with the new product or the control dimeticone group (NYDA). This effect persisted at all observation points (100% efficacy). Efficacy of 0.5% permethrin (Infectopedicul) ranged between 76 and 96% in evaluations between 5 min and 6 hours. All lice treated with a coconut-based compound (mosquito Läuseshampoo) did not show major vital signs after 5 min, but mortality was only 58% after one hour. Pyrethrum extract (Goldgeist forte) showed an efficacy of 22 - 52% between 5 min and 3 hours after treatment; after 6 hours, 76% of lice were judged dead. An oxyphthirine-based compound (Liberalice DUO LP-PRO) killed 22 - 54% of lice in the first 6 hours.
The two-phase dimeticone compound NYDA sensitiv is highly efficacious. The removal of fragrances as compared to an established dimeticone product did not affect in vitro efficacy.
二甲基硅油通过物理方式杀死头虱。在此，我们通过比较生物测定法评估了“NYDA sensitiv”的体外疗效，这是一种新型的基于二甲基硅油的两相灭虱剂，类似于市场上已有的一种产品，但无香料。
我们将该新产品的疗效与二甲基硅油阳性对照组、德国市场上销售的其他四种杀虫和天然头虱产品的样本以及未处理对照组进行了比较。在生物测定中，按照标准方案，将虱子体外暴露于各产品中，并检查长达24小时的活性。
6小时和24小时后，未处理对照组中有13.7%和88.5%的虱子未显示主要生命体征。相比之下，用新产品或二甲基硅油对照组（NYDA）处理5分钟后，没有虱子显示主要生命体征。这种效果在所有观察点均持续存在（100%疗效）。在5分钟至6小时的评估中，0.5%氯菊酯（Infectopedicul）的疗效在76%至96%之间。用椰子基化合物（蚊虫头虱洗发水）处理的所有虱子在5分钟后均未显示主要生命体征，但1小时后死亡率仅为58%。除虫菊提取物（Goldgeist forte）在处理后5分钟至3小时之间的疗效为22% - 52%；6小时后，76%的虱子被判定死亡。一种基于氧硫磷的化合物（Liberalice DUO LP - PRO）在前6小时杀死了22% - 54%的虱子。
两相二甲基硅油化合物NYDA sensitiv高效。与已有的二甲基硅油产品相比，去除香料并未影响体外疗效。
