Department of Nutrition, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran.
Public Health Nutr. 2010 Sep;13(9):1395-402. doi: 10.1017/S1368980009992126. Epub 2009 Dec 15.
Although recent studies have shown an inverse relationship between dairy consumption and metabolic abnormalities, we are aware of no study evaluating the association between dairy consumption and circulating levels of inflammatory markers. The current study was undertaken to assess the association between the consumption of high-fat and low-fat dairy products and circulating levels of inflammatory markers among Tehrani women aged 40-60 years.
In a cross-sectional study of 486 apparently healthy women aged 40-60 years, we assessed usual dietary intakes by means of an FFQ. Anthropometric measurements were made and fasting blood samples were taken for measuring inflammatory markers.
The reported mean (SD) daily intake of low- and high-fat dairy consumption was 85 (SD 23) and 101 (SD 29) g/d, respectively. After control for age, BMI, waist circumference and other potential confounders, low-fat dairy consumption was inversely associated with C-reactive protein (beta = -0.04), IL-6 (beta = -0.02) and soluble vascular cell adhesion molecule-1 (beta = -0.06); with further adjustment for dietary intakes, the associations remained significant just for soluble vascular cell adhesion molecule-1 (beta = -0.03). High-fat dairy intake was positively associated with log-transformed values of serum amyloid A (beta = 0.08) and soluble vascular cell adhesion molecule-1 (beta = 0.05), both before and after adjustment for all potential confounding variables. No overall significant associations were found between total dairy consumption and inflammation.
The current study indicates an independent relationship between high-fat as well as low-fat dairy consumption, not total dairy intake, and some markers of inflammation and endothelial dysfunction. Further studies are required to identify responsible components of dairy products and related mechanisms of action.
尽管最近的研究表明乳制品的摄入与代谢异常呈负相关，但我们尚未发现评估乳制品摄入与循环炎症标志物水平之间关系的研究。本研究旨在评估高、低脂乳制品的摄入与 40-60 岁的伊朗女性循环炎症标志物水平之间的关系。
在一项 486 名 40-60 岁的看似健康的女性的横断面研究中，我们使用食物频率问卷评估了习惯性的饮食摄入量。进行了人体测量学测量，并采集空腹血样以测量炎症标志物。
报告的低脂肪和高脂肪乳制品的每日平均（SD）摄入量分别为 85（SD 23）和 101（SD 29）g/d。在控制年龄、BMI、腰围和其他潜在混杂因素后，低脂乳制品的摄入量与 C 反应蛋白（β=-0.04）、IL-6（β=-0.02）和可溶性血管细胞黏附分子-1（β=-0.06）呈负相关；在进一步调整饮食摄入量后，可溶性血管细胞黏附分子-1的相关性仍然显著（β=-0.03）。高脂肪乳制品的摄入量与血清淀粉样蛋白 A（β=0.08）和可溶性血管细胞黏附分子-1（β=0.05）的对数值呈正相关，在调整所有潜在混杂变量之前和之后均如此。总乳制品摄入量与炎症之间未发现总体显著关联。
本研究表明，高脂肪和低脂乳制品的摄入与某些炎症和血管内皮功能障碍标志物之间存在独立关系，而非总乳制品摄入量。需要进一步的研究来确定乳制品中负责的成分和相关的作用机制。
