Keshavarz Zahra, Rahimlou Mehran, Farjam Mojtaba, Homayounfar Reza, Khodadost Mahmoud, Abdollahi Ashkan, Tabrizi Reza
Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.
Department of Nutrition, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
Front Nutr. 2022 Sep 9;9:962834. doi: 10.3389/fnut.2022.962834. eCollection 2022.
BACKGROUND/OBJECTIVES: There are limited data on the association between dairy products consumption and nonalcoholic fatty liver disease (NAFLD). This study was conducted to evaluate the association between total intake of different dairy products and fatty liver index (FLI), a marker of subclinical fatty liver.
A total of 7,540 adults were included in this population-based cohort study. Dairy products consumption was evaluated by a validated interview questionnaire for food intake frequency. The FLI was calculated using the standard formula. Liver enzyme levels, lipid profiles, glycemic profiles and demographic characteristics were recorded for all participants. Univariate and multiple logistic regression models were used to respectively assess the mean percentage difference of mean FLI and odds ratios (ORs) for subclinical NAFLD across quantiles of dairy consumption.
The mean age of all participants was 48.81 ± 9.631 years. FLI measurements for men and women were 26.71 ± 23.39 and 39.99 ± 26.64 respectively, which was significantly higher in women ( < 0.05). Multiple logistic regression analysis demonstrated that the amount of milk consumption was an independent preventive predictor of FLI (OR = 0.96; 95% CI: 0.94-0.99), conversely, it did not predict higher levels of liver enzymes. In term of cheese intake, participants in the third tertile of cheese intake had significantly lower FLI than lower tertiles ( = 0.01). However, there wasn't any significant association between cheese intake and the odds of FLI in the multivariate model ( > 0.05). We didn't find any significant association between yogurt consumption and NAFLD indicators ( > 0.05).
Higher milk consumption was inversely associated with FLI. However, there wasn't any significant association between other types of dairy products and NAFLD indicators.
背景/目的：关于乳制品消费与非酒精性脂肪性肝病（NAFLD）之间关联的数据有限。本研究旨在评估不同乳制品的总摄入量与脂肪肝指数（FLI，一种亚临床脂肪肝的标志物）之间的关联。
本基于人群的队列研究共纳入7540名成年人。通过一份经过验证的食物摄入频率访谈问卷评估乳制品消费情况。使用标准公式计算FLI。记录所有参与者的肝酶水平、血脂谱、血糖谱和人口统计学特征。单因素和多因素逻辑回归模型分别用于评估乳制品消费分位数间FLI的平均百分比差异以及亚临床NAFLD的比值比（OR）。
所有参与者的平均年龄为48.81±9.631岁。男性和女性的FLI测量值分别为26.71±23.39和39.99±26.64，女性显著更高（<0.05）。多因素逻辑回归分析表明，牛奶消费量是FLI的独立预防预测因素（OR = 0.96；95%CI：0.94 - 0.99），相反，它并未预测肝酶水平升高。就奶酪摄入量而言，处于奶酪摄入量第三分位的参与者的FLI显著低于较低分位者（=0.01）。然而，在多变量模型中，奶酪摄入量与FLI的比值之间没有任何显著关联（>0.05）。我们未发现酸奶消费与NAFLD指标之间存在任何显著关联（>0.05）。
较高的牛奶消费量与FLI呈负相关。然而，其他类型的乳制品与NAFLD指标之间没有任何显著关联。
