Novartis Animal Health Canada, Inc., Calgary, Alberta T2V 4M6, Canada.
Anim Health Res Rev. 2009 Dec;10(2):155-8. doi: 10.1017/S1466252309990211.
Advances over the last 20 years in immunology and molecular biology have provided many new tools for identifying the important antigens and new ways to achieve the appropriate immune responses to these antigens. These provide many more options to achieve the best immune response from deletion mutations, subunit antigens, vectors or DNA immunization. These tools are being adopted to screen, discover and produce the appropriate antigens and to deliver them by the optimal method and with novel adjuvants to achieve the appropriate immune response. These developments will result in vaccines for respiratory disease that are safer and more efficacious, and provide greater flexibility for use and administration.
在过去的 20 年中，免疫学和分子生物学的进展为鉴定重要抗原提供了许多新工具，也为实现针对这些抗原的适当免疫反应提供了新方法。这些方法为通过缺失突变、亚单位抗原、载体或 DNA 免疫来实现最佳免疫反应提供了更多选择。这些工具正在被用于筛选、发现和生产适当的抗原，并通过最佳方法和新型佐剂来递送它们，以实现适当的免疫反应。这些发展将导致更安全、更有效的呼吸道疾病疫苗，并为使用和管理提供更大的灵活性。
