血红素抑制细胞培养中的人类免疫缺陷病毒1复制，并增强齐多夫定的抗病毒效果。
Heme inhibits human immunodeficiency virus 1 replication in cell cultures and enhances the antiviral effect of zidovudine.
作者信息
Levere R D, Gong Y F, Kappas A, Bucher D J, Wormser G P, Abraham N G
机构信息
Laboratory of Metabolism and Pharmacology, Rockefeller University Hospital, New York, NY 10021.
出版信息
Proc Natl Acad Sci U S A. 1991 Mar 1;88(5):1756-9. doi: 10.1073/pnas.88.5.1756.
Abstract
The effects of heme alone and heme administered together with 3'-azido-3'-deoxythymidine (AZT) on human immunodeficiency virus replication in human peripheral blood lymphocytes and in the H9 cell line were studied. Heme enhanced the antiviral action of AZT against both drug-resistant and drug-sensitive viral strains; the heme effect was more pronounced against the latter. Moreover, heme alone displayed a significant ability to inhibit viral replication in concentrations markedly smaller than those required to inhibit the reverse transcriptase of Rauscher murine leukemia virus. The results of this study extend the range of pharmacological actions that metalloporphyrins exert in biological systems and suggest that further study of the interactions of the natural compound heme and human immunodeficiency virus chemotherapeutic agents such as AZT may be useful.
摘要
研究了单独的血红素以及与3'-叠氮基-3'-脱氧胸苷（AZT）一起施用的血红素对人外周血淋巴细胞和H9细胞系中人类免疫缺陷病毒复制的影响。血红素增强了AZT对耐药和药物敏感病毒株的抗病毒作用；对后者的血红素作用更明显。此外，单独的血红素在浓度明显低于抑制劳氏肉瘤病毒逆转录酶所需浓度时就显示出显著的抑制病毒复制的能力。这项研究的结果扩展了金属卟啉在生物系统中发挥的药理作用范围，并表明进一步研究天然化合物血红素与人类免疫缺陷病毒化疗药物如AZT之间的相互作用可能是有用的。
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Heme inhibits human immunodeficiency virus 1 replication in cell cultures and enhances the antiviral effect of zidovudine.血红素抑制细胞培养中的人类免疫缺陷病毒1复制，并增强齐多夫定的抗病毒效果。
Proc Natl Acad Sci U S A. 1991 Mar 1;88(5):1756-9. doi: 10.1073/pnas.88.5.1756.
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Porphyria cutanea tarda associated with the acquired immune deficiency syndrome.迟发性皮肤卟啉症与获得性免疫缺陷综合征相关
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