Division of Consultative and Diagnostic Medicine, Mayo Clinic, Jacksonville, Florida, USA.
Nutrition. 2010 Mar;26(3):255-62. doi: 10.1016/j.nut.2009.08.020. Epub 2009 Dec 8.
Recent evidence has suggested a role for vitamin D in breast cancer prevention and survival. Studies have reported an inverse relation between vitamin D intake and the risk of breast cancer, improvements in survival after a diagnosis of breast cancer in women with higher levels of vitamin D, and vitamin D insufficiency in up to 75% of women with breast cancer. Preclinical data have indicated that vitamin D affects up to 200 genes that influence cellular proliferation, apoptosis, angiogenesis, terminal differentiation of normal and cancer cells, and macrophage function. Vitamin D receptors have been found in up to 80% of breast cancers, and vitamin D receptor polymorphisms have been associated with differences in survival. Although ongoing studies have investigated a possible link between adequate levels of vitamin D and improved cancer prognosis, breast cancer survivors may derive additional, non-cancer-related benefits from adequate vitamin D levels, including improvements in bone mineral density, quality of life, and mood. Maintaining adequate vitamin D stores is recommended for breast cancer survivors throughout their lifetime.
最近的证据表明维生素 D 在预防和生存乳腺癌方面具有一定作用。研究报告称，维生素 D 摄入量与乳腺癌风险呈负相关，维生素 D 水平较高的女性在被诊断出患有乳腺癌后，其生存率有所提高，多达 75%的乳腺癌患者存在维生素 D 不足。临床前数据表明，维生素 D 可影响多达 200 种基因，这些基因影响细胞增殖、细胞凋亡、血管生成、正常细胞和癌细胞的终末分化以及巨噬细胞功能。高达 80%的乳腺癌中发现了维生素 D 受体，维生素 D 受体多态性与生存差异有关。虽然正在进行的研究调查了维生素 D 水平充足与改善癌症预后之间的可能联系，但乳腺癌幸存者可能从充足的维生素 D 水平中获得额外的、与癌症无关的益处，包括改善骨密度、生活质量和情绪。建议乳腺癌幸存者终生保持充足的维生素 D 储存。
