微小 RNA 在胰腺癌中的作用：病理、诊断和治疗意义。
MicroRNA in pancreatic cancer: pathological, diagnostic and therapeutic implications.
机构信息
Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
出版信息
Cancer Lett. 2010 Jun 1;292(1):8-16. doi: 10.1016/j.canlet.2009.11.010. Epub 2009 Dec 9.
Abstract
MicroRNAs (miRNAs) are a group of small non-coding RNA molecules of 17-25 nucleotides (nt) in length, predicted to control the activity of about 30% of all protein-coding genes in mammals. Altered expressions of miRNAs are reported in various cancers and may associate with cancer pathogenesis, apoptosis, and cell growth, thereby functioning as either tumor suppressors or oncogenes. Recent reports showed that deregulation of miRNA contribute to tumor development and progression and hence, have diagnostic and prognostic value in several human malignancies. This review discusses the current status of miRNA in pancreatic cancer development, progression, diagnosis, and therapy.
摘要
微小 RNA（miRNA）是一组长度为 17-25 个核苷酸（nt）的小型非编码 RNA 分子，据预测可以控制哺乳动物中大约 30%的所有蛋白质编码基因的活性。在各种癌症中报道了 miRNA 的表达改变，并且可能与癌症发病机制、细胞凋亡和细胞生长有关，因此作为肿瘤抑制因子或癌基因发挥作用。最近的报告表明，miRNA 的失调有助于肿瘤的发展和进展，因此在几种人类恶性肿瘤中具有诊断和预后价值。本综述讨论了 miRNA 在胰腺癌发展、进展、诊断和治疗中的现状。
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