Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA.
Department of Biotechnology, Kumaun University, Nainital, Uttarakhand 263001, India.
Genes (Basel). 2019 Sep 25;10(10):752. doi: 10.3390/genes10100752.
Pancreatic cancer is one of the most aggressive malignancies, accounting for more than 45,750 deaths annually in the U.S. alone. The aggressive nature and late diagnosis of pancreatic cancer, coupled with the limitations of existing chemotherapy, present the pressing need for the development of novel therapeutic strategies. Recent reports have demonstrated a critical role of microRNAs (miRNAs) in the initiation, progression, and metastasis of cancer. Furthermore, aberrant expressions of miRNAs have often been associated with the cause and consequence of pancreatic cancer, emphasizing the possible use of miRNAs in the effective management of pancreatic cancer patients. In this review, we provide a brief overview of miRNA biogenesis and its role in fundamental cellular process and miRNA studies in pancreatic cancer patients and animal models. Subsequent sections narrate the role of miRNA in, (i) cell cycle and proliferation; (ii) apoptosis; (iii) invasions and metastasis; and (iv) various cellular signaling pathways. We also describe the role of miRNA's in pancreatic cancer; (i) diagnosis; (ii) prognosis and (iii) therapeutic intervention. Conclusion section describes the gist of review with future directions.
胰腺癌是最具侵袭性的恶性肿瘤之一，仅在美国每年就有超过 45750 人因此死亡。胰腺癌具有侵袭性和晚期诊断的特点，再加上现有化疗的局限性，迫切需要开发新的治疗策略。最近的报告表明，微小 RNA（miRNA）在癌症的发生、发展和转移中起着关键作用。此外，miRNA 的异常表达通常与胰腺癌的病因和后果有关，这强调了 miRNA 在有效管理胰腺癌患者方面的可能用途。在这篇综述中，我们简要概述了 miRNA 的生物发生及其在基本细胞过程中的作用，以及 miRNA 在胰腺癌患者和动物模型中的研究。随后的部分叙述了 miRNA 在（i）细胞周期和增殖；（ii）细胞凋亡；（iii）侵袭和转移；和（iv）各种细胞信号通路中的作用。我们还描述了 miRNA 在胰腺癌中的作用；（i）诊断；（ii）预后和（iii）治疗干预。结论部分描述了综述的要点和未来方向。
