比较 F-18 FET 和 F-18 FDG 用于疑似脑肿瘤患者评估的 PET 研究。
Comparative PET study using F-18 FET and F-18 FDG for the evaluation of patients with suspected brain tumour.
机构信息
Centre for Molecular Imaging, Peter MacCallum Cancer Centre, 12 Cathedral Place, East Melbourne, Victoria 3002, Australia.
出版信息
J Clin Neurosci. 2010 Jan;17(1):43-9. doi: 10.1016/j.jocn.2009.05.009. Epub 2009 Dec 9.
The aim of this prospective pilot study in patients with suspected or known brain tumour was to establish the diagnostic value of O-(2-[(18)F]-fluoroethyl)-L-tyrosine (FET) positron emission tomography (PET) when compared to fluorine-18 fluorodeoxyglucose (FDG) PET. Twenty-five FET PET and FDG PET scans were performed on 21 consecutive patients within 24 months. Final malignant pathology included 11 glioma (eight low-grade, three high grade), two lymphoma, one olfactory ganglioneuroblastoma, one anaplastic meningioma. Benign pathology included two encephalitis and one cortical dysplasia. Definitive pathology was not available in three patients. The accuracy of PET was determined by subsequent surgical histopathology in 12 and clinical/imaging course in nine patients. Median follow-up period was 20 months. FET sensitivity was 93%, specificity 100%, accuracy 96%, positive predictive value (PPV) 100% and negative predictive value (NPV) 91%. FDG sensitivity was 27%, specificity 90%, accuracy 52%, PPV 80% and NPV 45%. FET PET is more accurate than FDG PET for detecting malignant brain lesions, especially low-grade gliomas.
本前瞻性研究旨在探讨氟代乙基酪氨酸（FET）正电子发射断层扫描（PET）与氟代脱氧葡萄糖（FDG）PET 相比，在疑似或已知脑肿瘤患者中的诊断价值。21 例连续患者在 24 个月内进行了 25 次 FET PET 和 FDG PET 扫描。最终恶性病理包括 11 例胶质瘤（8 例低级别，3 例高级别）、2 例淋巴瘤、1 例嗅神经母细胞瘤、1 例间变性脑膜瘤。良性病理包括 2 例脑炎和 1 例皮质发育不良。3 例患者未获得明确的病理结果。12 例患者通过随后的手术组织病理学和 9 例患者的临床/影像学病程确定了 PET 的准确性。中位随访时间为 20 个月。FET 的灵敏度为 93%，特异性为 100%，准确性为 96%，阳性预测值（PPV）为 100%，阴性预测值（NPV）为 91%。FDG 的灵敏度为 27%，特异性为 90%，准确性为 52%，PPV 为 80%，NPV 为 45%。FET PET 比 FDG PET 更准确地检测恶性脑病变，尤其是低级别胶质瘤。
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