Ciber Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Spain; Servicio de Endocrinología y Nutrición, Hospital Clínico Virgen de la Victoria, Málaga, Spain.
Servicio de Cardiología, Hospital Regional Universitario Carlos Haya, Málaga, Spain.
Int J Cardiol. 2010 Nov 19;145(2):263-264. doi: 10.1016/j.ijcard.2009.09.472. Epub 2009 Dec 11.
Several studies show the association between anti-oxidized LDL antibodies and atherosclerosis. A certain association also seems to exist between the levels of these antibodies and treatment with statins. However, the clinical importance of these autoantibodies is still under discussion. The aim of this study was to determine whether levels of anti-oxidized LDL antibodies are associated with the presence of multivessel coronary artery disease according to whether statins were or were not being taken.
The study included 236 patients who underwent invasive coronary angiography with quantification of coronary atherosclerotic lesions to determine the presence of multivessel coronary artery disease. Measurements were made of IgG and IgM anti-oxidized LDL antibodies. In the group of patients who were taking statins, the percentage of patients with IgM anti-oxidized LDL antibodies below 50th percentile was significantly higher in those with multivessel coronary artery disease (57.4% vs. 37.5%, P<0.05). A logistic regression model in the patients taking statins showed that the variable significantly associated with the presence of multivessel coronary artery disease was the level of IgM anti-oxidized LDL antibodies.
The severity of multivessel coronary artery disease was inversely related with the levels of IgM anti-oxidized LDL antibodies, especially in the patients on statins.
多项研究表明，抗氧化型 LDL 抗体与动脉粥样硬化之间存在关联。这些抗体的水平似乎也与他汀类药物治疗之间存在一定关联。然而，这些自身抗体的临床重要性仍在讨论中。本研究旨在确定根据是否正在服用他汀类药物，抗氧化型 LDL 抗体的水平是否与多支冠状动脉疾病的存在有关。
本研究纳入了 236 例接受了冠状动脉造影术并对冠状动脉粥样硬化病变进行定量分析的患者，以确定是否存在多支冠状动脉疾病。测量了 IgG 和 IgM 抗氧化型 LDL 抗体。在服用他汀类药物的患者中，多支冠状动脉疾病患者中 IgM 抗氧化型 LDL 抗体低于第 50 百分位数的百分比明显高于无多支冠状动脉疾病的患者（57.4%比 37.5%，P<0.05）。在服用他汀类药物的患者中，逻辑回归模型显示，与多支冠状动脉疾病存在显著相关的变量是 IgM 抗氧化型 LDL 抗体水平。
多支冠状动脉疾病的严重程度与 IgM 抗氧化型 LDL 抗体水平呈负相关，尤其是在服用他汀类药物的患者中。
